ID A0A2U9BAU5_SCOMX Unreviewed; 1530 AA.
AC A0A2U9BAU5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Putative transient receptor potential cation channel subfamily M member 1-like {ECO:0000313|EMBL:AWP01083.1};
GN ORFNames=SMAX5B_007988 {ECO:0000313|EMBL:AWP01083.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP01083.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP01083.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP026247; AWP01083.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000007315; -.
DR Proteomes; UP000246464; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF13; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:AWP01083.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 825..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 892..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 960..981
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1037..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..381
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 833..1071
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1167..1221
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1320..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1530
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1530 AA; 172434 MW; 3D43FEEFBBF631FE CRC64;
MDNRGRRGTN GSFKQSSIKR SASSGSQKIH RVWIERTFQK RECIQIIPSK DASRCSCGQM
VAQHTILPGA RDEGPPLVQL EGQAAEKWSP LKHTQTSPTD AYGVIEFQGG GHVNKAMYIR
VSYDSKPDSL LHLMVKDWQL ELPTLLISVH GGLQNFDLPP KLKQVFGKGL IKAAVTTGAW
IFTGGVSTGV IRHVGDALKD HSSKSRGKVC AIGIAPWGII ENKEDLIGRD VTRPYQTMSN
PLSKLSAPNG SHSHFILSDN GTSGKYGAEV RLRRQLEKHI ALQKINTRLG QGVPVVCLIL
EGGPNVISIV LESLREDPPV PVVVCDGSGR ASDIISFAHR YCEEDGLVSD SVKDQLLVTI
QKTFNYSRSQ AQQIFLMVME CMKKRALITV FRMGSEGQQD IEMSILTALL KGTNASASDQ
LSLALAWNRV DIARSQIFVF GLHWPVNSLE QAMMDALVLD RVDFVKLLIE NGVNIHHFLT
IPRLEELYNT KLGPANTLHF VVRDVKKGNL PPDYQITLID IGLVLEFLMG GAYRCKYTRK
SFRTLYNNLY GLKRPKALKL LGMEDDEPRA KGKGKKNKKK EEEVDIDIDD PEVSRFQYPF
HELMVWAVLM KRQKMALFLW QRGEEAMAKA LVACKLYKAM AHESSQSELV DDIYQDLENN
SREFGQLAYE LLDQSYKHDE QVAMKLLTYE LKNWSNSTCL KLAVAAKHRD FIAHTCSQML
LTDMWMGCLR MGKSNCLKVI LGIVFPPAIL LMDFRLGEEA SCHSSKESND SKSKDDDDKS
SKDAVSNVDA TSKKGDEEEN QKKSRKRIPI GKMIYEFYNA PYTKFWFNTI SYLVYLMLYN
YIILVKMERW PSLQEWIVIS YIITLGLEKV RQILMSEPGK LKQKINVWLE DYWNITDLAA
ISVFLLGLLL RLQNEPYMGH GRVIYCVDII FWYIRVLDIF GVNKYLGPYV MMIGKMMIDM
LYFVVIMLVV LMSFGVARQA ILHPDEVPTW RLARNIFYMP YWMIYGEVFA DSIDPPCGDN
MYDEDGKKLP PCIPGAWLTP AIMACYLLVA NILLVNLLIA VFNNTFFEVK SISNQVWKFQ
RYQLIMTFHD RPILPPPLIV LPHIYIVLKR LCCRCRRRPE GERDDRERRL QLMLSADELK
SLHEFEEQCV EEYFREKDDE KQSSNNERIR VTSERVENMF MRLEEVNERE HSMKASLQTV
DLRLSQLEEF SGRMMNALEK LAGVDRAELV RSRSRGSSVC EPSALLRHGS INSSDGYSLY
RYQLEHDDRV SVSGDTEGHD RRIQLSPERR GRDAAGDVKE FGSTLEVRAL KDRTQSLSSV
DIRISPCDPD LRTPGAPPAS PHPHPTDAGT EKPAEKSRLE AAASFPLEAS KVTEYLVSAS
LSGSASSDRK SLSNIVCSSA PQDQEDAVSL TQQTTGRGEE TKQEEEEPRS SDISPPCSPP
DGNHGNMEGE EPSEQLLVGE DRMYPTLRSK SLNANPRKTR TKRKEDEETP RSASSVRDLV
SAFSGGAGGH GPEPGPGPGP GPEPGPGPDL
//
