ID A0A2U9BC68_SCOMX Unreviewed; 889 AA.
AC A0A2U9BC68;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Groucho 1 {ECO:0000313|EMBL:AWP01410.1};
GN ORFNames=SMAX5B_012497 {ECO:0000313|EMBL:AWP01410.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP01410.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP01410.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; CP026247; AWP01410.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9BC68; -.
DR STRING; 52904.ENSSMAP00000034862; -.
DR Proteomes; UP000246464; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF24; TRANSDUCIN-LIKE ENHANCER PROTEIN 3; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 148..262
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 689..730
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 731..772
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 73..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 156..190
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 270..284
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 96085 MW; 9209D12548C7B46F CRC64;
MAAAPCSVIS RTTDTSPRVL VVSIRGRYVA TDSEAKFIEL DFSSIHDQGA SLARCDSAAF
FCLFRYKGKR AGDEVTSSRS GSEGAPRSRG QGFVRRHRAH PGEGVAVIYR TFGGTTERDT
ARTPSCVGLD MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL
ANEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNAILA QIMPFLSQEH QQQVAQAVER
AKQVTMTELN AIIGQQLQAQ HLSHAAHGPP VQLPPHPSGL QPPGIPPVTG AGSGLLALGA
LGSQAHLPVK DEKNHHDLEH RERESSTNNS VSPSDSLRAA SEKHRSSSDY GLDSKKRKVD
DKDRYDSDGD KSDDLVVDVS NEDPATPRVS PAHSPPENGL DKSRVLKKDA APNSPASVAS
SGSTPSSKAK DHTHNDKSST PSLKSNTPTP RNEAPTPGTS TTPGLRPLTM GKPPGMEALA
APALRTPLSI AGSYATPFAM MSHHEMNGSL TSPGVYPGLI SPQMSAAAAA AYGRSPIAGF
DPHSHLRAPG LPSSLTSISG GKPAYSFHVS ADGQMQPVPF PPDALVGPGI PRHARQINTL
SHGEVVCAVT ISNPTRHVYT GGKGCVKIWD ISQPGSKSPV SQLDCLNRDN YIRSCKLLPD
GRTLIVGGEA STLTIWDLAS QTPRIKAELT SSAPACYALA ISPDAKVCFS CCSDGNIAVW
DLHNQTLVRQ FQGHTDGASC IDISHDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF
SLGYCPTGEW LAVGMESSNV EVLHHTKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL
LNAWRTPYGA SIFQSKESSS VLSCDISADD KYIVTGSGDK KATVYEVIY
//
