ID A0A2U9BKP2_SCOMX Unreviewed; 1053 AA.
AC A0A2U9BKP2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Integrin, alpha 6b {ECO:0000313|Ensembl:ENSSMAP00000007009.1};
DE SubName: Full=Putative integrin alpha-6-like {ECO:0000313|EMBL:AWP04259.1};
GN Name=LOC118311752 {ECO:0000313|Ensembl:ENSSMAP00000007009.1};
GN ORFNames=SMAX5B_006633 {ECO:0000313|EMBL:AWP04259.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP04259.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP04259.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSMAP00000007009.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; CP026249; AWP04259.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000007046; -.
DR Ensembl; ENSSMAT00000007098.2; ENSSMAP00000007009.1; ENSSMAG00000004319.2.
DR GeneTree; ENSGT00940000155353; -.
DR Proteomes; UP000246464; Chromosome 7.
DR Proteomes; UP000694558; Chromosome 7.
DR Bgee; ENSSMAG00000004319; Expressed in pharyngeal gill and 5 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 21..1053
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5041003048"
FT TRANSMEM 1008..1030
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 22..90
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 174..227
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 242..299
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 301..362
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 363..420
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 425..484
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 469..628
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 630..784
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 790..997
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 883..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 114675 MW; 3FB2BB016E6F70E0 CRC64;
MAAPLTRALW LLVGLLGCEA FNLDTEHVQR KSGEPGSLFG FSLALHRQLE PQDKRMLLVG
APKAKATKGQ KAKVTGGLYS CDTSSISTSC VRVNFDDEED LTSESKENQW MGVSVSSQGP
GGKIVTCAHR YQRRANVNSA MASRDILGRC YVLSQNLKIS PGLEEEGGDW HFCDRRARGH
EMFGSCQQGL SATFDKDYHY LIFGAPGAYN WRGVVRLEQR NLSLVDQGIF DDGPFETGGE
SEKNPNLVPA PANSYLGFSL DSGRSLTKKG YLTVVAGAPR ANHSGAVVLM KIGLDLSKSL
VGEYTLEGEG LASSFGYDLA VLDLNGDGWQ DIVVGAPQYF EKDGKIGGAV YVYVNQAGDW
NKVKPTRIDG PMDSMFGLAV ESLGDINLDG YHDFAVGAPY ADEGSGNVYI YSGSATGLSS
KKALQVLSGK PLGVRMFGYS LAGNMDLDKN SYPDLAVGSL SDSVFVYKSR PVINIKKEIN
FSPKEIDLTK KNCGSSFCLD IEACFTYTAN PKSYAPKLTV VYSLVADADL TRDGLIHRGT
FIGSSASDKV YESKGTITMN SKGAKQCVTR KLAIQENIRD KLRGIPIDVS VDIQEAKRKR
RQSSASLAPV LDPRDPMTTR SQVHFLKEGC GIDNVCQSNL QVEYRYGHRA TDKDTFVPLE
LDNGMPLISL SNQNDIALEV TVTNLNGDDA HEASLAASFP RSLAYSTYVV PPSDRHVTCR
ANKDGSKLDC DLGNPFKRDS KATIYIILGT AGISVSTTEL EIDLQFNTTS DQQNIAPVKA
KAKVAIMLQL SVTGQIQPSQ VYFSGEAKDD RAMKTESDTG IAITHQFRII NLGKPLKDFG
SASLNIMWPK GTTQGKRLLY LMKISSTGVD KLDCSPKDEI NSLGLEPSST RARRSAGSSK
RSDEGTLSRF TETKESIALS CDNGAQCVTI KCPLRGLDSN AVITVHSRLW NSTFIKDYSK
MHHVEVIVKA SLHVDSTSKN TFLKNAETQA RLTVFPEMLA AQYGGVPWWI IVLSILFLLL
LLGLLAFLLW KCGVFGKKNK EEPPEKETLT SNA
//
