ID A0A2U9BP32_SCOMX Unreviewed; 230 AA.
AC A0A2U9BP32;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Voltage-dependent calcium channel gamma-1 subunit {ECO:0000256|ARBA:ARBA00019950, ECO:0000256|RuleBase:RU363085};
DE AltName: Full=Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma {ECO:0000256|ARBA:ARBA00029680, ECO:0000256|RuleBase:RU363085};
GN Name=CACNG1 {ECO:0000313|Ensembl:ENSSMAP00000029862.1};
GN ORFNames=F2P81_010474 {ECO:0000313|EMBL:KAF0037600.1}, SMAX5B_007369
GN {ECO:0000313|EMBL:AWP05904.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP05904.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP05904.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF0037600.1, ECO:0000313|Proteomes:UP000438429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ysfricsl-2016a {ECO:0000313|EMBL:KAF0037600.1};
RC TISSUE=Blood {ECO:0000313|EMBL:KAF0037600.1};
RA Xu H., Xu X.-W., Shao C., Chen S.;
RT "Draft genomes of female and male turbot (Scophthalmus maximus).";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSSMAP00000029862.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulatory subunit of the voltage-gated calcium channel that
CC gives rise to L-type calcium currents in skeletal muscle. Regulates
CC channel inactivation kinetics. {ECO:0000256|ARBA:ARBA00003367,
CC ECO:0000256|RuleBase:RU363085}.
CC -!- SUBUNIT: Component of a calcium channel complex consisting of a pore-
CC forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or
CC CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta,
CC gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either
CC CACNB1 or CACNB2. {ECO:0000256|RuleBase:RU363085}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004415}. Membrane
CC {ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU363085}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
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DR EMBL; CP026250; AWP05904.1; -; Genomic_DNA.
DR EMBL; VEVO01000009; KAF0037600.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000029862; -.
DR Ensembl; ENSSMAT00000030231.2; ENSSMAP00000029862.1; ENSSMAG00000018315.2.
DR GeneTree; ENSGT00390000007786; -.
DR OMA; YVEGHGC; -.
DR OrthoDB; 4230292at2759; -.
DR Proteomes; UP000246464; Chromosome 8.
DR Proteomes; UP000438429; Unassembled WGS sequence.
DR Proteomes; UP000694558; Chromosome 8.
DR Bgee; ENSSMAG00000018315; Expressed in muscle tissue.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR005421; VDCC_g1su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR15025:SF8; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT; 1.
DR PANTHER; PTHR15025; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED; 1.
DR Pfam; PF13903; Claudin_2; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01601; VDCCGAMMA1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU363085};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU363085};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU363085};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU363085};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU363085}; Membrane {ECO:0000256|RuleBase:RU363085};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Transmembrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363085};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU363085}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 108..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 141..164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 184..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
SQ SEQUENCE 230 AA; 25761 MW; F31D889BDBE5034B CRC64;
MHKRTKIKIA IFVLLVGMAC TFTAVVTDHW AVLSPRVERV NETCEAAHFG LWRLCKKNIY
MSSENYVEGQ GCGPISLPGE ENCTYFGHFT PGQDTEIFEY KTQKEYNISA AAISIFCLAF
MILGSLCLLG SCTGKGKGRD YLLKPSGMFF AFAGLCLFIS LEVMRQSVKR MIESEDTIWI
VFNYGWSFAC ACSGFVLLFL TGIALLVLSM PQMPRNPWET CMDAEPDQVE
//
