ID A0A2U9BR52_SCOMX Unreviewed; 1861 AA.
AC A0A2U9BR52;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE SubName: Full=Putative dedicator of cytokinesis protein 5 {ECO:0000313|EMBL:AWP06688.1};
GN ORFNames=SMAX5B_010986 {ECO:0000313|EMBL:AWP06688.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP06688.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP06688.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CP026251; AWP06688.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000002935; -.
DR Proteomes; UP000246464; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF3; DEDICATOR OF CYTOKINESIS PROTEIN 5; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 443..626
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1228..1639
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1671..1751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1770..1861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 191..218
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1671..1698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1699..1719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1728..1747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1850
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1861 AA; 214327 MW; 8B14248A7BE431EF CRC64;
MTRWIPTKKE KYGVAIYNYD PSGEQELCLQ VGDTVHILEK LEGWYRGYTL RKKSQKGIFP
ASYIHLKEAT FEGIGQQEII IPADLPLVQE LGATLREWAQ IWHTLFVANK TTQFRSVQQM
AYSLIEYRSQ IVSGTLPKDD LVELKKKVTA KIDYGNRILG LDLVVRDIAG NTLDPDRTST
VSLYRAHETA SRSVDDRIQE EKTRLQNLER QRQTLFSTVH TYSLLMNLKN FVCNIGEDAE
LLMSLYDPDQ SEFISENFLV RWDSMGMPKE IEKLNNLPAL FTDLSSSDLM RQRLFLVCQI
IRVGSMELKE GKKHTGGLRR PFGVAVMDIT DVAHGKTDDE DKQHFIPFQQ IAMETYIRQR
QLIMSPLIPS RVIGENEPLT AVFNKVIATR EVNHKGQGLF VTLKLLPGDL AQVRKDYPHF
VDRSTAIVRK MGFPEIILPG NVRNDIYITL LQGEFDRGKK KTPKNVEVIL TVHDDEGNPM
EKAIFPGAGY DGITEYKSVI YYQVKQPCWN ETVKVTIPIE DVCRCHLRVM FRHRSSQDSR
DKSEKPFGMA FVRLMRGDGT TLKDGRHELI VYKVDVKKAE DAKVYLNLPA TWGEVEEKEK
QTGKQFHHSG VIPVTKDSFQ IATLTCSTKL TQNVDLLGLL NWRSNPEALD QILQRLMEVE
GGEIVKFLQD TLDALFNIMM ETSEKDTYDT LVFNALVFII TLIGDIKFQH FNPVLETYIN
KHFSATLAYM KLTGVLNYYV GHAEEPILTE KLYVALKALK YLFRFIVQSR DLYLRFYGNS
EDGDAFFNSI RTLFLSFNTL MDRPLDEGVK IKGAILKYLP SIINDIQTVF DPVELSVLLA
KFIESIPDSQ LVRQKLGCMC KMVESDLFRQ PDCRDVLLPL VTDQLSGQLD DHSSKPDYEA
CVQLLSTVLD NLDRKDVGPT RGHVQLIMER LLRRVNRTVI SMDRSSPLIG HYLACMTAIL
KQMDDMHYAH YISTFKTRQD IIDFLMETFI MFKDLMGNIF PADWMIMNLV QMQVFLRAID
EYSDVLNMYF LDQAHFELQL WNNYFHLTVA FLTHKTLQLE SFSQEKRNKI LNKYGDMRKI
VGFKIRDMWY NLGPHKMRFI PAMVGPILEV TLVPEPELRK ATIPIFFDMM QCEHNFNPGR
TFEMFENELI TKLDQEVEGG QGDEQYKVLL EKTLLEHCRR HRYLSQSGEE LALLLSSLLE
NLLAYRTITH DESPEHRMSC TVNVLNFYKE KKREDIYIRY LYKLRDLHLD CENYTEASYT
LLLHAELLEW SDKACAPHLI PRDGEHVWTQ QELKERLFQE IICYLDKGKM WEKAIELGKQ
LAKMHEIHMF DFMELSQLLK KQAKFYENIM HAMRPQPEYF AVGYYGLGFP SFLRNKMFIY
RGKEYEWLED FSLKLLSQFP SAVRMTSTAP PGDNISNSPG QHIQCFTVKP VLTVPQQFKD
KGVPEQILNY YRTNEVDQFK YSRPFRKGEK DPDNEFATMW IERTTYITAY HFPGILKWFE
VKSVSVEEIS PLENAVETME MANEKLSNLV QQQACDRSLS INPLSMMLSG IVDPAVMGGF
SNYEKAFFTD SYIQEHPEDH ERIEVLKHLI ALQIPLLADG IHIHGEKTTE QLKPLHNRLV
TCFQDLREKV EKQYGVITLP CSLTEKKKSR VGSVVMPYIL SSTLRRMSTV STHSTASSGL
SSGSASSDGP SCISSQDDRR ASVMEEDNRI ARKNRKEWSV SKSQVLLERQ TDTEETPPEK
QQRPKSLQLG DRRLTLSLFQ GGLSQLSLSN PLSPLPASPH TPHTLRSSSY SSLLSDNDAN
IIDTPGTPPP MPPKKHPHEI DNPRFSSEFT PPLPVKIESK PPPPPPKTRK SMFPSYEHTP
Q
//
