ID A0A2U9BXW5_SCOMX Unreviewed; 1782 AA.
AC A0A2U9BXW5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Putative brefeldin A-inhibited guanine nucleotide-exchange protein 2-like {ECO:0000313|EMBL:AWP09155.1};
GN ORFNames=SMAX5B_011633 {ECO:0000313|EMBL:AWP09155.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP09155.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP09155.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
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DR EMBL; CP026253; AWP09155.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000003678; -.
DR Proteomes; UP000246464; Chromosome 11.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF124; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 635..824
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 195..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1782 AA; 201179 MW; 7BF2521F67DE8711 CRC64;
MFLSRALEKI LSDKEVKRSQ HGQLRKACQV ALDEIKAELE KQKDGTVVPP RANYIEADKY
VLPFELACQS KSPRIVSTSL DCLQKLIAYG HITGNAPDSR SPGKRLIDRL VETICNCFQG
PQTDEGVQLQ IIKALLTTVT SPHIEIHEGT VLLTVRTCYN IYLASRNLIN QTTAKATLTQ
MLNVIFTRME NQAALEAQEQ EKERLRPPQQ NPSPVPGNRR SGSPWSDRTP TPEPQSYLSP
AASTPDLTTT NTISSTPPQP SAADLDLDLD QDQDQDQAPD TQSINGEPER GNERMNGGEE
QVTPSDGGEH PAPPVPEQTE VAPPRVRAEG QQMNGIIEDR SSVSSTDMLD AEGLQGPHNA
ARFSHILQKD AFLVFRSLCK LSMKPLADGP PDPKSHELRS KIVSLQLLLS VLQGAGPVFR
THEMFVNAIK QYLCVALSKN GVSSVPEVFE LSLAIFLTLL SHFKVHLKMQ IEVFFREIFL
TILETSTSSF EHKWMVIQTL TRICADAQCV VDIYVNYDCD LNAANIFERL VNDLSKIAQG
RSGQELGMTP LQELSLRKKG LECLVSILKC MVEWSKDMYV NPNLLANLGQ EHPPDSDGGE
MKLSEQLVGR RDSISSLDST VSSSLPASQA DHPEQYEVIK QQKDIIEHGI ELFNKKPKRG
VQYLQDQGML ASAAEDIAQF LHQEDRLDTT QVGEYLGENI KFNIEVMYCY VDQLDFLGRD
FVSALRAFLE GFRLPGEAQK IDRLMEKFAA RYLECNQGQT LFASADTAYV LAYSIIMLTT
DLHSPQVKNK MTKEQYIKMN RGINDSKDLP EEYLSSIYDE IAGKKIAMKE SKEFSITPKS
TKQSVASEKQ RRLLYNMEME QMAKTAKALM EAVSHAQAPF FSATHLEHVR PMFKLAWTPL
LAAFSVGLQD CDDPEVASLC LEGIRCAIRI ACIFSMQLER DAYVQALARF TLLTASSSIT
EMKQKNIDTI KTLITVAHTD GNYLGNSWHE ILRCISQLEL AQLIGTGVKT RYISGVVRDK
EAGIKGLPSG TEEFMPLGLG NLVGSQDKRQ MAHIQESVGE TSSQSVVVAV DRIFTGSTRL
DGNAIVDFVR WLCAVSMDEL ASAHQPRMFS LQKIVEISYY NMNRIRLQWS RIWQVIGDHF
NKVGCNPNED VAIFAVDSLR QLSMKFLEKG ELANFRFQKD FLRPFEHIMK KNRSPTIRDM
VIRCVAQMVN SQAANIRSGW KNIFSVFHQA AADHDETIVE LAFQTTGHIV TNTFREHFAA
AIDSFQDAVK CLSEFVCNAA FPDTSMEAIR LIRHCAKYVS ERPQALREYT SDDMNVAPGD
RVWVRGWFPI LFELSCIINR CKLDVRTRGL TVMFEIMKSY GHTFEKHWWH DLFRIVFRIF
DNMKLPEQQT EKTEWMTTTC NHALYAICDV FTQFYEPLSE ILLVDIFTQL QWCVRQDNEQ
LARSGTNCLE NLVILNGEKF SPEVWKITCS CMLEIFQNTS PHVLLTWRPA GQDEETADGK
HFDADFDSQS QSSYDRALSE RGHSQMSSDD TWKGKSNARV SDQKLFAGLL IKCVVQLELI
QTIDNIVFYP ATSKKEDAEN MAAAQRDALE ESEGSELGPD QGMYRHMTSA HLFKLLDCLL
ESHTFAKDFN SNNEQRTALW RAGFKGKSKP NLLKQETSSL ACSLRILFRM YSDPQLQDSW
PDIQTRLLLV CSEALAYFIS LTSESHREAW NSLLMLLLTR TLRLPDDKFK PHASCYYPQM
CEMMQFDLIP ELRAVLRRFF LRIGSVFHIA SPEAASARSP AS
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