ID A0A2U9BYX2_SCOMX Unreviewed; 695 AA.
AC A0A2U9BYX2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 08-NOV-2023, entry version 14.
DE SubName: Full=Putative DNA repair protein complementing XP-C cells isoform 2 {ECO:0000313|EMBL:AWP09371.1};
GN ORFNames=SMAX5B_002752 {ECO:0000313|EMBL:AWP09371.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP09371.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP09371.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; CP026253; AWP09371.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9BYX2; -.
DR Proteomes; UP000246464; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR NCBIfam; TIGR00605; rad4; 1.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464}.
FT DOMAIN 377..429
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 431..490
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 497..571
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 82..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..204
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 77924 MW; A3A175863DDE60AB CRC64;
MVAKERIDQN YLSGLLKWFR ATFTLNPSLP CEERPDPRAL LERRLASLSA KNHQEMTHLF
LLVLRSLQLF CRLVLSLQPI PFKPPSAKGK GARTSNCASE KTSTTQETSK TTSSDTKVSP
GTKRPAAGGK AKGSRGGKKA KRKDIKEEEE SSVKSGGPRP KNSKRRTVAS KVSYKEESHS
EGGEGLSDEE EFQVTSDEDS EDSESEAEST KKEKGRGKTK VIKNKNTAVG GGGKKRVKDE
GDNEREEGED DGGVEEGTTN NYAKRRRGKK EEGPGADEWL EVYLEKTSSW VCVHVEHGVA
MPHLCSRSAT APVTYVVSVD GDGFVKDLGR KYDPTWMTSS RKRRVDEDWW DETLQPFLGP
EDEKDKREEK ELQNKLLNKP LPISIAEYKN HPLYALRRHL LKYEAIYPPT ASVLGYCRGE
PVYSRDCVHT LHSRDTWLKE ARTVRLGEEP YKMVKGSSNR SRKARIMAEL KDGNDLPLFG
EWQTEEYQPP IAVDGKVPRN DYGNVYFFKP CMLPVGCIHL RLPNLHRVAK KLEMDAAPAV
TGFDFHGGFS HAVTDGYIVC EENEEILQAA WLEEQELQKE KEKEKREKRV ISNWTLLVKG
LLIRERLKQR YGKKNPGLGG LAHGDNTGGL SSDEEEAVEG GSPGAKTASE TLAMSWPQNR
QAEEDGGNSS GLTKKSTTKR EKRGQEKHMF PFEKV
//
