ID A0A2U9C1D0_SCOMX Unreviewed; 1048 AA.
AC A0A2U9C1D0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Putative integrin alpha-5-like {ECO:0000313|EMBL:AWP10178.1};
GN ORFNames=SMAX5B_014827 {ECO:0000313|EMBL:AWP10178.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP10178.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP10178.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; CP026253; AWP10178.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9C1D0; -.
DR STRING; 52904.ENSSMAP00000033995; -.
DR Proteomes; UP000246464; Chromosome 11.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF3; INTEGRIN ALPHA-5; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..1048
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016020452"
FT TRANSMEM 998..1020
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 41..106
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 122..183
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 188..240
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 307..372
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 373..432
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 436..499
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 633..774
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 780..988
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1048 AA; 114838 MW; 2321A36C16721724 CRC64;
MGLERFRVKT QRTVALLPRA LLCAIVGLSL PAPPPACEAF NLDVESPAVY SGPRGSYFGY
AVDFYLADSS SASVVIGAPK ANTRQVNVTE GGSVFYCPWN LGQSDCHAIE FDAEGDRSVS
LNNTEHQVDF KSHQWFGATV RSHGDTILAC APLYSWRTEK DTPHSDATGT CYLSIHNFTK
FVEYAPCRTE ISGEGGQGYC QGGFSADFTS DGKVVLGGPG SYFWQGQVIS AAKEDIIKAY
YPGYFMQSVE GQIQTKQVHS AYDDSYQGYS VAVGEFSGDQ VEDFVAGVPK GLMLYGSVSI
LNGTDLKTMI NYTGEQMGSY FGYAVATTDI NSDGMADLLV GAPMFMVRGS GGRLEEMGRV
YVYLQRGPLN MELRLPHITG TQAFGRFGST IAPLGDLNQD GFNDVAISCP FGGEDRQGLV
YIFNGYSGGL REKPSQVIAG QWAAGTIPAS FGFSLRGAKD LDMNGYPDLI VGAFGVNKAV
LYRSRPIVNA SASLTVYPTM INPEEKSCMV TSGNTSVPVS CLRFQRRGEE TDDGCLLLNM
VDTVLIDIPC LRKGSSVGRR LPLPPLFYMI IRCCGAPGRR GVWSERGSPH ERCDVGTLAS
AGSCALSSSE AASFSYVTNG KGVCVRAQIL LDCGEDNICV PDLKLAVHGD KREVYLGDDN
SLTLTFNAKN EGEGGAYEAE LYVVLPPEAD YSGIARNNES LTQLTCSFEM ENQTRYLSCD
LGNPMKSGTS LWAGLRFTVP RLKDTHRTVQ FEMQIRSKNE NNSHSEAVPY KLEVVVQAEV
ILQGVSRPDK VFFPPANWKV TKNYGAEQDV GPAVEHIYEL VNNGPSRISH TLLELRCPLS
VQGHNLLYPL EFSTEGPVNC TADRNMNHLH LKLQHTSTEP PILALKAQEH RVERRDVHRN
QLAHLTNLSC SNVECWSLRC KVGLLEKGTT AILKVRSRVW AETFTERAYK QYVLECLARY
SVEKMPYAIL PRHAPSGHKK VVTPVVWNKP DIENSVPLWI IILAILAGLL LLALLIYVLY
KFGFFKRSLP YGTAMEKAQL KPQAASEA
//
