ID A0A2U9C1X2_SCOMX Unreviewed; 355 AA.
AC A0A2U9C1X2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Neuronal differentiation 4 {ECO:0000313|Ensembl:ENSSMAP00000003801.2};
DE SubName: Full=Putative neurogenic differentiation factor 4 {ECO:0000313|EMBL:AWP09666.1};
GN Name=neurod4 {ECO:0000313|Ensembl:ENSSMAP00000003801.2};
GN ORFNames=SMAX5B_014954 {ECO:0000313|EMBL:AWP09666.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP09666.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP09666.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSMAP00000003801.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; CP026253; AWP09666.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000003801; -.
DR Ensembl; ENSSMAT00000003864.2; ENSSMAP00000003801.2; ENSSMAG00000002363.2.
DR GeneTree; ENSGT00940000160217; -.
DR OrthoDB; 2915590at2759; -.
DR Proteomes; UP000246464; Chromosome 11.
DR Proteomes; UP000694558; Chromosome 11.
DR Bgee; ENSSMAG00000002363; Expressed in brain.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0021986; P:habenula development; IEA:Ensembl.
DR GO; GO:0001839; P:neural plate morphogenesis; IEA:Ensembl.
DR GO; GO:0071698; P:olfactory placode development; IEA:Ensembl.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
DR CDD; cd19721; bHLH_TS_NeuroD4_ATOH3; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR022575; NeuroD_DUF.
DR PANTHER; PTHR19290; BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED; 1.
DR PANTHER; PTHR19290:SF86; NEUROGENIC DIFFERENTIATION FACTOR 4; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12533; Neuro_bHLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 98..150
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..70
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..106
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 38696 MW; CFC8F0FBBFF2FA48 CRC64;
MMTKPFGKNG DMSDLVSSLG WLEEEEDGSS QDGDESPEMR GHHGLIHSCT ELGSEDMDEE
EEEEVDGDDI GPNGENAPKR RGPKKKKMTK ARQERFRARR VKANARERSR MHGLNDALES
LRRVMPCYSK TQKLSKIETL RLAHNYIWAL SEVLESGQSP ESHGFMEMLC KGLSQPTSNL
VAGCLQLGPS PMMLNKLEDK CGGPGVGGMG GQAGHPLSYP SPGLPSPPYG SLEASHLLHM
KGFKGPVYDN PSSNECSSGT PPYDGPLTPP LSISGNFALK QEPSPRESER NFTPHPGHHA
HYLLSHHYPT STTGGLPGGP QSHPLFQASR YELPLDVAYD SFTPSHLVTS QMGSI
//
