ID A0A2U9C2M0_SCOMX Unreviewed; 556 AA.
AC A0A2U9C2M0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Putative mucolipin-2 isoform 2 {ECO:0000313|EMBL:AWP10887.1};
GN ORFNames=SMAX5B_022567 {ECO:0000313|EMBL:AWP10887.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP10887.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP10887.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP026254; AWP10887.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9C2M0; -.
DR STRING; 52904.ENSSMAP00000004497; -.
DR OMA; CDADRWE; -.
DR Proteomes; UP000246464; Chromosome 12.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21071; ELD_TRPML2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF4; MUCOLIPIN-2; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 275..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..261
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 363..499
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 556 AA; 64374 MW; DF4484116A889235 CRC64;
MELLVRYLER RSSASSVMTQ DIIKEENLRD DLRYYFMSPC EKYRTRRQKP WKLGVQILKI
VMITTQLILF GLNNQLVVSY KEENTMALKN IFLKDFRGVD EDDYSVAVYT QHGVYESLFH
VLDQYSQLGR LSTGPITYAE DEDGKLLPLI VCKQHYKRGI VQPSDEAYDM DAQLETVCLS
HDPKTANLQR THNSSFFDLD FYRLVDITIT FQLKGINLQT VRSRELPDCY LFHVTITFDN
QCHSGKVKIF LDTDAQSSTC RDWKISGTAQ KNTHYLLIFD GFVILVCLTS AVLCTRSIVL
AVRLLQRFSR FFRENYNRKV CEDDQSEFLN GWYVLVIVSD LLAIIGTILK MEIQAKSLTS
YDVCSIFLGT STLMVWVGVI RYLGYFQKYN VLILTMKAAF PKVLRFCCCA GMIYLGYTFC
GWIVLGPYHE KFEGLSRVAE CLFSLVNGDD MFTTFAQLKD KNTLVWLFSR AYLYSFISLF
IYMVLSLFIA LITDAYETIK NYQRDGFPLT DLQKFLRAQK DFPVAEESSQ TEDHVRSSVF
CCCQRVPEND DVILIS
//