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Database: UniProt
Entry: A0A2U9C2M0_SCOMX
LinkDB: A0A2U9C2M0_SCOMX
Original site: A0A2U9C2M0_SCOMX 
ID   A0A2U9C2M0_SCOMX        Unreviewed;       556 AA.
AC   A0A2U9C2M0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Putative mucolipin-2 isoform 2 {ECO:0000313|EMBL:AWP10887.1};
GN   ORFNames=SMAX5B_022567 {ECO:0000313|EMBL:AWP10887.1};
OS   Scophthalmus maximus (Turbot) (Psetta maxima).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC   Scophthalmus.
OX   NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP10887.1, ECO:0000313|Proteomes:UP000246464};
RN   [1] {ECO:0000313|EMBL:AWP10887.1, ECO:0000313|Proteomes:UP000246464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Martinez P.;
RT   "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT   evaluation of genetic and physical mapping variation across individuals.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP026254; AWP10887.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U9C2M0; -.
DR   STRING; 52904.ENSSMAP00000004497; -.
DR   OMA; CDADRWE; -.
DR   Proteomes; UP000246464; Chromosome 12.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   CDD; cd21071; ELD_TRPML2; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF4; MUCOLIPIN-2; 1.
DR   Pfam; PF21381; MCLN_ECD; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        275..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        403..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        471..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          77..261
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          363..499
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
SQ   SEQUENCE   556 AA;  64374 MW;  DF4484116A889235 CRC64;
     MELLVRYLER RSSASSVMTQ DIIKEENLRD DLRYYFMSPC EKYRTRRQKP WKLGVQILKI
     VMITTQLILF GLNNQLVVSY KEENTMALKN IFLKDFRGVD EDDYSVAVYT QHGVYESLFH
     VLDQYSQLGR LSTGPITYAE DEDGKLLPLI VCKQHYKRGI VQPSDEAYDM DAQLETVCLS
     HDPKTANLQR THNSSFFDLD FYRLVDITIT FQLKGINLQT VRSRELPDCY LFHVTITFDN
     QCHSGKVKIF LDTDAQSSTC RDWKISGTAQ KNTHYLLIFD GFVILVCLTS AVLCTRSIVL
     AVRLLQRFSR FFRENYNRKV CEDDQSEFLN GWYVLVIVSD LLAIIGTILK MEIQAKSLTS
     YDVCSIFLGT STLMVWVGVI RYLGYFQKYN VLILTMKAAF PKVLRFCCCA GMIYLGYTFC
     GWIVLGPYHE KFEGLSRVAE CLFSLVNGDD MFTTFAQLKD KNTLVWLFSR AYLYSFISLF
     IYMVLSLFIA LITDAYETIK NYQRDGFPLT DLQKFLRAQK DFPVAEESSQ TEDHVRSSVF
     CCCQRVPEND DVILIS
//
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