ID A0A2U9C3S0_SCOMX Unreviewed; 3283 AA.
AC A0A2U9C3S0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=SMAX5B_014637 {ECO:0000313|EMBL:AWP09692.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP09692.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP09692.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CP026253; AWP09692.1; -; Genomic_DNA.
DR Proteomes; UP000246464; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 19.
DR Gene3D; 2.10.25.10; Laminin; 12.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 19.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 6.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR032485; LRP1-like_beta_prop.
DR PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 18.
DR Pfam; PF00058; Ldl_recept_b; 9.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 19.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 19.
DR SMART; SM00135; LY; 29.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 18.
DR SUPFAM; SSF63825; YWTD domain; 6.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 7.
DR PROSITE; PS50068; LDLRA_2; 19.
DR PROSITE; PS51120; LDLRB; 16.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3163..3184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 158..204
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 205..247
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 248..294
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 476..518
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 563..602
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 781..823
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 824..866
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 867..910
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1189..1233
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1234..1276
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1828..1868
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 1915..1959
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1960..2002
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2003..2046
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2047..2089
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2706..2748
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2749..2792
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2933..2966
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2969..3005
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3041..3077
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3114..3145
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2659..2685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3262..3283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2659..2676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 16..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1377..1395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1411..1423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1418..1436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1430..1445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1450..1462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1457..1475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1469..1484
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1518..1533
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1541..1553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1548..1566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1560..1575
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1579..1591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1586..1604
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1672..1690
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1705..1717
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1751..1763
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1758..1776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1770..1785
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1832..1842
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2180..2192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2187..2205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2220..2232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2227..2245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2239..2254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2279..2294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2382..2394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2389..2407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2444..2459
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2468..2480
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2475..2493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2937..2947
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2973..2983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2995..3004
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3045..3055
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3067..3076
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3135..3144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3283 AA; 366719 MW; A50083738C6CEAD9 CRC64;
MCATNDSICL PAEKLCDGTD DCPDGSDEKL CDLCALDNGG CSHNCSIIPG EGFMCSCPLG
MELGADNKTC HIQSFCAKHL KCSQKCEQEK SSVKCSCYEG WELESDMESC KSTDPFKPFI
IFSNRHEIRR IELHKGEFSV LVPGLRNTIA LDFHLNESTL YWTDVVEDKI YRGKLSENGA
LTSFEVVIQY GLATPEGLAV DWIAGNIYWV ESNLDQIEVA KLDGTMRTTL LAGEVEHPRA
IALDPRDGIL FWTDWDASLP RIEAASMSGE GRRTIHRETG SGGWPNGLTV DYMERRIVWI
DARSDAIYSA MYDGSGLIEV LRGHEYLSHP FAVTMYGGEV YWTDWRTNTL AKANKWTGHN
VTVVQRTNTQ PFDLQVYHPS RQPQAPNPCA TSDGRGPCSH LCLINFNQTF SCACPHLMKL
QPDRRTCKES RKFLLYARQI EIRGVDIDNP YYNYIISFTV PDIDNVTAVD YDAVEHRIYW
SDVRTQTIKR AFINGTGVET VVSADLPNAH GLAVDWVSRN LFWTSYDANK KQINVARLDG
SFKNAVIQGL DKPHCLVVHP LLGKLYWTDG DNISMANMDG SNRTTLFTNQ KGPVGLSIDY
EKEQLYWISS VNSTINRCQM DGSKLEIMEG VKGKLTKATA LAIMGDKLWW ADQGSDQIGT
CDKSDGGNWK VMRNNTSPMM HMRIYDEEVQ QAGINLCSNN NGDCSQLCLP TSHTTRACMC
TAGYSLKTGQ QSCEGMGSFL LYSVHEGIRG IPLDPADKSD ALVPVSGTSL AVGIDFHAEN
DTIYWVDMGL STISRAKRDQ TWREDVVTNG IGRVEGITVD WIAGNIYWTD QGFDVIEVAR
LDGSFRYVVI SQGLDKPRAI TVHPVKGYLF WTEWGQYPRI ERSRLDGSQR LVLVNVSISW
PNGISIDYEE SLLYWCDART DKIERINLET GENRELVLAN NNMDMFAVSV FEEYIYWSDR
THANGSIKRG NKDNATDAVQ LRTGIGVQLK DIKVFNRARQ QGTNVCKNNG GCEQLCLYRG
NGERTCACAH GMLAEDNRSC RDYDGYLLYS ERTILKSIHL SDETNLNAPI KPFEDPDHMK
NVIALSFDYH GGGGKGANRV FFSDIHFGNI QQINDDGTDR KIVVDNVGSV EGLAYHRGWD
TLYWTSYTTS TITRHTVDQS RSVAYNRNTV VTMSGDDHPR AFVLDECQDL MFWTNWNEQS
PSIMRASLNG ANVLVIIGKD IKTPNGLAID HRAEKLYFSD ATLDKIERCE YDGSSRYVLL
KNEPVHPFGL AVYGDYIFWT DWVRRAVLRA DKYTGGDMKV LRADIPQQPM GIVAVANDTN
NCEFSPCRIN NGGCQDLCLP TSDGRVNCSC RGDRQLLDDN TCASLNISCG SVDDFECGNG
DCINYSLTCD GMAHCKDKSD EKQSYCANRI CKKGYRRCMN GRCIGHQFWC DGTDDCGDHS
DELPCNMTLC KVGEFQCKDG SCISNFSRCD QVVNCEDASD EMNCQATDCA RFFRLGVKGA
SFQSCEKTTL CYLPSWVCDG NNDCGDYSDE RNCPDKRKPK CPVNFFACPS GRCIPMSWTC
DKENDCENGA DETHCDKFCT STQFECGNHR CISSHWVCDG SDDCGDGSDE DQKCKSKTCS
PEAFQCPGSH MCVPQRWKCD GDKDCPDGAD ESVKAGCMYT NNTCDAENEF MCQNRQCIPK
HFVCDHDIDC SDGSDESPEC EYPTCGPDEF RCANGRCLNQ KKWECDGEFD CQDRSDEAPK
NPRCTDTERT CNDSAFMCHN GKCLNETLLC DRNDDCGDGS DELNCFINEC LNSKLSGCSQ
LCDDLKIGFK CRCHPGFQLK RDGKTCVDID ECTTTYPCSQ RCINTHGSFH CLCVDGFELN
PNDPTICKST SEEEPYLIFA NRYYLRKLNL DGSNYTLIKQ GLNNAVALDF HYAEQMIYWT
DVTTQGSMIR RMHMNGSNIE VLHRTSLSNP DGLAVDWVGG NLYWCDKGRD TIEVSKLNGA
YRTVLVNNGL REPRAVAVDV RYGYLYWSDW GDNPHIGRIG MDGTNRSVIV EDKITWPNGL
TLDFINDRIY WADAREDYIE FASLDGTNRH TVLSQDIPHI FAMTLFEEYI YWTDWETKSI
NRAHKSLGTN KTTLISTLHR PMDIHIYHPY RQPEVLNHPC QTNNGGCSNL CLLSPGGGYK
CACPTNFYLA NDQRTCMSNC TASQFVCKND KCIPFWWKCD TEDDCGDRSD EPAECPEFKC
RPGQFQCGTG ICTNPAYICD GDNDCQDNSD EANCDIHVCL PSQFKCSHPS RCIPGIFRCN
GQDNCGEGED EKDCPEVTCA PTQFQCAITK RCIPRVWVCD RDNDCVDGSD EPANCTQMTC
GVDEFRCKDS GRCIPARWKC DGEDDCGDAS DEPKEECAGR HCPQDEFQCN NTLCKPLAWK
CDGEDDCGDN SDENPEQCRR FQCPPTRAFR CHNDRVCLQV SKRCDGVNNC GDNSDELNCQ
APPAVPTCEK DEFLCANSRC ISSTLRCNFF NDCEDYGSDE INCKTDTKLN DCRSNRTQCG
DGDEAHCVTN GTDSFCACKP GFKKMGHQTC RDKNECLQFG VCSHMCNNTK GSYKCSCHKY
FTRIHDTCKA DNMNSSRQVL YIADDNEIRS LDPGMPNWRY EQTFQGDASV RIDAMDLHVK
SNRIFWTNWH TGRISSYELP GPSTSSSSSS SSNSHRNRRQ SEGRITNLQI KELKMPRGIA
VDWVAGNLYW TDSGRDVIEV AQMSGQHCKT LISGMIDEPY AIVVDPQRGT MYWADWGNHP
KIETAAMDGT LRQTLVHENI QWPTGLAVDY FNERLYWADA KLSVIGSVRL DGSDAVIAVS
GIKNNLLHPF SIDVFEDYIY GVTYINNVVF RVNKFGKGPM ENLTTGINHA TDIVLYHRYK
QPEMTNPCDR KKCEWLCLLS PSGPVCTCPN NYMADNGTCV ERPNPTQSPF SPPSGPCDIQ
CQNGGSCFLN ARQVAKCRCQ PSYTGERCEI NQCRDYCKNG GTCTASHTGA ATCRCPKGFT
GPTCNRHTCQ DYCVNGGNCS VNMGNQPTCS CPSEYLGDQC QYSQCEGYCH NGGTCLQTAN
STKLCQCPTQ YIGYQCELDK CLFCGTGKCL TSSSGEVSCS CPNGQTQPSC YSCLDYCANG
QCSVDTRTLL PQCKCPVGWT GYRCEVAAAS VDSSASSGST ASIVIPVLLL LLLALLVVGA
ILWYKRRMRG AKGFQHHRMT NGAMNVEIGN PAYKIYEGDP DDDAGELLDS DFALDPDKPT
NFTNPVYATL YMGAHNSRNS LASTDEKKEL LSQGDEDLSD PLA
//
