ID A0A2U9CIK8_SCOMX Unreviewed; 980 AA.
AC A0A2U9CIK8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=SMAX5B_013830 {ECO:0000313|EMBL:AWP15579.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP15579.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP15579.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; CP026258; AWP15579.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9CIK8; -.
DR STRING; 52904.ENSSMAP00000019610; -.
DR Proteomes; UP000246464; Chromosome 16.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 410..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 198..278
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 569..710
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 108038 MW; 1B4969531A43404F CRC64;
MAMNVRRPRD VNDSRNKEEN ADVSRGGEMN SERETSGRNG RRIRLAREGA GSLILMGFLE
SLSLMESYPP GARGEALQHG QSGTLPQFLE EPVDAYIIKS NPIKLRCRAR PALQIFFKCN
GEWVHQSQHI SQEHTDLGTG LKIREVMINV SRQQVEDFHG PEDYWCLCVA WSHLGTSKSR
KAAVRIAYLR KNFEQDPQGT EVPLNGMIVL HCRPPEGVPV AEVEWLKNDE PLSSDGVIDT
RGDHNLIISD ARLSDSGNYT CVASNIVAKR RSATATVVVY VNGGWSSWTD WSPCNVRCGR
GMQKRSRTCT NPAPLNGGGF CEGMSVQKST CNTLCPVDGS WGEWSEWSLC SPSCERQRSR
DCTAPEPKHG GRLCDGVAVA TDNCTGGLCT QNRKLLHEVK PQGVENSSDV ALYSGLAAGV
VTVVLLIVAV TLYRRSQSEY GVDVIDSSAL TGGFQSFSFK TSHQANPLLI NSSMQPDLTV
SRTYTSPMCF QDSIDKELMA ERSLLDPLPD LKVKGVAERA EYHVMSHPQT FPRGLAPDYR
GVAVGTTLGR RGKNLFPPQV SLTLSRPLHK ATAVFGHAGG RLVVPNTGIS LLVPHGGIAE
DTTWEMYMII NQEDSSSLFA DGPEIFLSPA VTYGPPGLDL SCPIAMTVAH CAEVADDNWT
IRLKRQTQDN KWEEVMSVDE ESTSCYCLLE AQRCQVLLQH PGRYALVGEP LNQDVSKRLR
LAVFGSPDTS SSLGFTLRVY CVDDTPHAFQ EVVVGERSRG GRLLEEPKMM LFRGNTFSLQ
VSIQDVPQLL WSIKPFTTCQ EFSFSQVWAS NQRPLQCAFS LERYSHSSSQ LSCKVSVRQV
KGEEQILQVY TSVVENEKGV VPFFTQSDCT ITSQTGSRAF KIPPSIRQRI SATFDTANAK
GKDWQLLAQK LHIDRNLCYF ACQESPSSVI LSLWEAQHQD SGDLDSLASA LEEIGKVQSP
TSATLGSSRG ERDSEFTKLG
//
