ID A0A2U9CJ80_SCOMX Unreviewed; 917 AA.
AC A0A2U9CJ80;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR005813};
GN ORFNames=SMAX5B_000273 {ECO:0000313|EMBL:AWP16547.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP16547.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP16547.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR005813}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005813}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|PIRNR:PIRNR005813}.
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DR EMBL; CP026259; AWP16547.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9CJ80; -.
DR STRING; 52904.ENSSMAP00000005262; -.
DR Proteomes; UP000246464; Chromosome 17.
DR GO; GO:0032301; C:MutSalpha complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03243; ABC_MutS_homologs; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|PIRNR:PIRNR005813};
KW DNA repair {ECO:0000256|PIRNR:PIRNR005813};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR005813};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005813};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464}.
FT DOMAIN 733..749
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 100876 MW; F637943459707B73 CRC64;
MIHGSTEEGT AGGGHTWAAT PTGRGGLNET TSCGPRSTSS ASSQHGLDGG SASCSRGPAP
ARPPGATGQF HHSLTRSNPL LLTTTSDSSS TRSHGGTPRL RRTPGAAGTH PAQTPLTDHT
ATGCSSATTT SAASVIVAVV EGRGLARGEI GMASLNLKCP ELALCQFADT GTYAKVITKM
HILVPLEILM PDTASEKGKG TKLFKLITEN FPCVAFTAIQ RKYFNERKGL EYIQQLCAPE
FGTVLMEVQA KYYCLAAAAA LLKYLEFIQN SVYAAKSLKV SFKGSEQTTM IDSASATNLE
LVVNNRDRRS EHTLFGVLNH TKTPGGARRL RSNILEPLVD VDTINMRLDA VQELLQDEEL
FFGLKNAIGH FLDIDQLLSV LVQIPKQETV QVAEAKITHV IQLKHTLDLV PQLRAVLKNC
NTSLLKAYSS SLEDNRFDLI LEQIKTVIND ETTYLKGSLN MRTQKCYAVR PNVNEFLDIA
RRAYTEIVDD IAGLVNQTGE KYGMLMRTSF STARGFFIQM KLEGVVLPEG GLPPEFIKVT
KQKNNCGFTT ADLMKMNDRC DEALREIFHI SYVVICQLLS TIHEQIHCLY KLSDAVSMLD
MLLSLANACT ISDYVRPEFT DTLAIKQGRH PILERLAGQQ PVSNNSYISD GSNFVIITGP
NMSGKSTYLK QVALCQIMAQ IGSFVPADYA SFRVADQIFT RIGVDDDFET NSSTFMLEMR
EISYIIHNVS DRSLIIIDEL GRGTSAEEGI GICHSVCEFL LGLKAFTLFA THFLELCQLQ
SLYPSVENQH MEVQHTRSAD TGTERVVYTY LLNRGCSEER HYGLRAAEMT ALPTSLIEEA
KIIASNVSQQ LLAKHHSDPE TQRQRAVYHL ATRLQQAARN SRLDPDSLRM YLKGLRKQYE
AELQAAGQPA SMDTVEE
//