ID A0A2U9CNY7_SCOMX Unreviewed; 1400 AA.
AC A0A2U9CNY7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Tonsoku-like protein {ECO:0000256|ARBA:ARBA00017829};
DE AltName: Full=NF-kappa-B inhibitor-like protein 2 {ECO:0000256|ARBA:ARBA00033240};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 {ECO:0000256|ARBA:ARBA00030801};
GN ORFNames=SMAX5B_000286 {ECO:0000313|EMBL:AWP16422.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP16422.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP16422.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the Tonsoku family.
CC {ECO:0000256|ARBA:ARBA00010999}.
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DR EMBL; CP026259; AWP16422.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000032950; -.
DR Proteomes; UP000246464; Chromosome 17.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13176; TPR_7; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 354..387
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 524..556
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 557..589
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 593..625
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..499
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 153427 MW; 862456DC6EFCF093 CRC64;
MSSSREMKQL QKAKSKAQNS SNLKEEASIC NQLGELLSRH GDFEAAIREH QQELTLSEAL
NDVIGRAVAN RKIGECYAEM GNIEAALKHQ QWHLDLARSV RDHAEEQRAL ATIGRTYLFR
YESDQSRKSL EKAEDAFRKS LSIVDDRLEG MVPRREISEM KARLFLNLGL VCDHLGEPKR
CSEFIRRSVF IAEKSQLLED LYRANYNLGN IYFRNGQHSN SVRCLEQAKE CARKIKDKFS
ESECFHCIGK VQLSLGDFVA ARRSLKKALL LGSQQPLDRQ TVKKAFKYAD QGCKLEDELG
EDQGSRLSSH QAVELAEQLG DLYCKIGCYS KALDAYHAQL KGAEALGKAA RELAVIHVSL
AATYTDLRQH DRAVEHYRQE LALRQGSSSE ECRTWINIAA AQEESGSVSQ DTDSCYSTAL
LCAQKSGQAR LQKRVLRLWL ASQRRRGSSD ADDTEARLQE LCAAEGWSPE GSDGEEDEDE
EMDNSESLED SDVILSDSDD DMEGYDKMVS GRRKAGRWNK RNEKGETSLH RACIDGNLKQ
VQYLVEQGHP VNPRDYCGWT PLHEASNHGH YDIVAVLLEH GANVNDPGGP LCEGVTPLHD
ALACGNLQVA RLLVERGASV TQRNSKGNTA MDTLRQWQRT YSRELDQETK QECVATERLL
RKSQSGGVPA APAPAKPFDA LQDSQLFDAE NSEPLSSSGG GCSVGQVQTR HSRNSEVKAP
PASPKRWQSN GSAQRHRARG TEAAVLYGKN SICSDDSDSD SPVSPLRPVR PRHSFPAASS
QNEVPPKKET SSVPASVGVR EEPAPSVFAR QEYHSAIRGL GSAKSQLQGL SQPQFSSTPA
VSSSNKSALV PEEEYLADDW LDDDLGEIQP KKKRRLRVEQ NGINVEDTAL FSAVRSQTRH
LNSDTTDRGS AVPSSSSRSL SQKKNGSLRP HQPQAQTLAA PMPTSLPPPI RMRVRVQEDV
FLIPVPQSDA DSCKVSWLCE QAAQRYYQKC GLLPRLSLQK EGALLSPQDL LLAVLHTNEE
VLAEVCSWDL PPLPERYKKA CISLAVDENR RVTRLCEVQD GSSSVSVCGL SLAPSSLNPL
LRALKLQASL TELRISGNRL HDNLLPELIA TTVTMPRLRL LDISANHITG EGLGKAVNAL
KGQSHPAFPC LEELDLSLNP LGDGVSESLS CLLSCCPLLA KLSLQACGLT ARFLQQHRLL
LASALTGMGH LKSVCLAHNA LGSTGFELVL KTLPLHCLTH LDLSAVRRGP ADFPALEHLA
KVLSQDDCSL THLSLAANGL TDSSVATLAR CLPSCPSLLS LNLSGNSSLT SAGLHSILHS
LMEASRPLTL LNLQGCPVSG PWDSAGLDGL PELVKDLRLC SQGLNKLDRQ ALKQRWENSQ
PPGHFVDRKA KCLLSAAASS
//
