ID A0A2U9CR16_SCOMX Unreviewed; 493 AA.
AC A0A2U9CR16;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Histone-arginine methyltransferase CARM1 {ECO:0000256|ARBA:ARBA00021804};
DE EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
DE AltName: Full=Coactivator-associated arginine methyltransferase 1 {ECO:0000256|ARBA:ARBA00033236};
DE AltName: Full=Protein arginine N-methyltransferase 4 {ECO:0000256|ARBA:ARBA00030670};
GN ORFNames=SMAX5B_006097 {ECO:0000313|EMBL:AWP18370.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP18370.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP18370.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319;
CC Evidence={ECO:0000256|ARBA:ARBA00001817};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CP026261; AWP18370.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9CR16; -.
DR Proteomes; UP000246464; Chromosome 19.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd13330; PH_CARM1; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR020989; Histone-Arg_MeTrfase_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006:SF51; HISTONE-ARGININE METHYLTRANSFERASE CARM1; 1.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR Pfam; PF11531; CARM1; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015,
KW ECO:0000313|EMBL:AWP18370.1}.
FT DOMAIN 2..113
FT /note="Histone-arginine methyltransferase CARM1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11531"
SQ SEQUENCE 493 AA; 55403 MW; 155A1B857E368325 CRC64;
MAVSVFPGVR LLSIGDANGD IQRHSEQQPL RLEVKTTQDA ALINLSNGEE ASVFKCSVSR
ETECSRVGKQ SFIITLGCNS VLLQFSSPAD FQSFYNLLKN CRGHLSEHSV FSDRTEESSA
VQYFQFYGYL SQQQNMMQDY VRTGTYQRAI LQNHTDFKDK VVLDVGCGSG ILSFFAAQAG
ARKVYAVEAS TMAQHAEVLV NSNRLGERVV VIPGKVEEVT LSEQVDIIIS EPMGYMLFNE
RMLESYLHAK KFLKPNGKMF PTIGDVHLAP FTDEQLYMEQ FTKANFWYQP SFHGVDLSAL
RGAAVDEYFR QPIVDTFDIR ILMAKSVKYT VNFLEAKEED LYRIEIPFKF HMMHSGLVHG
LAFWFDVAFI GSVVTVWLST APTEPLTHWY QVRCLLQSPL FTKAGDTLSG TAMLVANKRQ
SYDISIVAQV DQTGSKSSNL LDLKNPFFRY TGSTPNPPPG SHYTSPSENM WNTGAYSMNQ
GMAVSGEQTH DHW
//
