ID A0A2U9CR52_SCOMX Unreviewed; 480 AA.
AC A0A2U9CR52;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Platelet-derived growth factor subunit B {ECO:0000256|ARBA:ARBA00018117};
DE AltName: Full=PDGF-2 {ECO:0000256|ARBA:ARBA00031888};
DE AltName: Full=Platelet-derived growth factor B chain {ECO:0000256|ARBA:ARBA00032481};
DE AltName: Full=Platelet-derived growth factor beta polypeptide {ECO:0000256|ARBA:ARBA00032702};
GN ORFNames=SMAX5B_006307 {ECO:0000313|EMBL:AWP18643.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP18643.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP18643.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|RuleBase:RU003818}.
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DR EMBL; CP026261; AWP18643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9CR52; -.
DR STRING; 52904.ENSSMAP00000011868; -.
DR Proteomes; UP000246464; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF2; PLATELET-DERIVED GROWTH FACTOR SUBUNIT B; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..480
FT /note="Platelet-derived growth factor subunit B"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015902470"
FT DOMAIN 68..171
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 169..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 53658 MW; 31F10A28894AA7D2 CRC64;
MSSWVKLLLV SLAACLRFGV AEGDPLPAAL VELVRNSPIS SIEDLQLLLL SDSVDEDGGT
SAANGGHRLP RSLDAQPAQQ ALCKVRTEVV EVTRAMLDRS NANFMLWPPC VEVQRCSGCC
NTKSLQCVPH VTHTRYLQVM KIEYINKRPT YTKAVVSVVD HVECRCQPVS RPPLPKKKSS
RRQHGHQHRN QTLSQEQAHG QVKMHSKDEL HQWDELKQNQ RAHLEDLLEQ HWSPRGDTFT
QPGEGYSLTG EDILFAPNWT HNSSRLHGTA DQSENPENAE GKDGGISDGN KTVSSVDNVG
VEVKDKLVVG GKELPLNSTD GKANEGNRSR DRGTETHVPL LHEDKFTKSH RSGVSQPVTE
NPPVKPRPTE EATGERGGRR FRPTKEPNPE SRELPRRRDN ETPEEERILQ MEEAKVEEER
KELLLLHKRD NDVHDHHAAA LGSCRPQTPS SPEPHEAKDE EESQTDQQGS YEGNANVELQ
//
