ID   A0A2U9CSU2_SCOMX        Unreviewed;       480 AA.
AC   A0A2U9CSU2;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=Putative short-chain dehydrogenase/reductase family 42E member 2 {ECO:0000313|EMBL:AWP18899.1};
GN   ORFNames=SMAX5B_020909 {ECO:0000313|EMBL:AWP18899.1};
OS   Scophthalmus maximus (Turbot) (Psetta maxima).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC   Scophthalmus.
OX   NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP18899.1, ECO:0000313|Proteomes:UP000246464};
RN   [1] {ECO:0000313|EMBL:AWP18899.1, ECO:0000313|Proteomes:UP000246464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Martinez P.;
RT   "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT   evaluation of genetic and physical mapping variation across individuals.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; CP026261; AWP18899.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U9CSU2; -.
DR   STRING; 52904.ENSSMAP00000025475; -.
DR   Proteomes; UP000246464; Chromosome 19.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        361..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          96..365
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   480 AA;  52786 MW;  39B6BBFBE8B96619 CRC64;
     MSETRGSLCQ VKPAPCHGVP LCRLQASGQH MHNLSHLSHQ PWVDQPAPAI VSSPAVAIRH
     RVNGAAAASC SSPVCVASRL GEEAALAQGV SMGTVLVTGG GGYFGFRLGR ELARQGMSVI
     LLDMNKPPCD VPDGATFYQS DIRDYPSLYK VSEGVDCIFH TASYGMSGPE QLKKEQVESV
     NVGGTNNVLN VCKERNIPRL VYTSTINVVF AGKPIEDGDE ASVPYVPHDL HIDHYSRTKA
     IAEQMVLSAN GCSLKGGELL RTCVLRSCGI YGPEERRHLH RVMVNVQRRL FSFRFGDPEA
     RMNWVHVDNL VLAHTLAAEA LTLKRNCVAN GQAYFINDGF SVNLFEWLTP LFEKMGYSRP
     LISLPVSLVY SAAILVEYLH VVLRPVIKVP LLFTRSEVRT IAVSHTFKID KAHRELGYCP
     ESYTLADSVE QHLKSLQSRS TSPLSNLSWT SQLPRRPVQL LLLLGLGLVL LMLSCILYQS
//