ID A0A2U9CZR9_SCOMX Unreviewed; 843 AA.
AC A0A2U9CZR9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
GN ORFNames=SMAX5B_015549 {ECO:0000313|EMBL:AWP21236.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP21236.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWP21236.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CP026264; AWP21236.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9CZR9; -.
DR STRING; 52904.ENSSMAP00000026819; -.
DR Proteomes; UP000246464; Chromosome 22.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 93..165
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 418..490
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 675..757
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 183..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..597
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 92507 MW; 5B6507D4C69F7D93 CRC64;
MDMAVNPLLD SSLIGVDVGF MGVTAMDQGS GAAGKRIRKP SLLYEGFESP GMPPISQMTA
LGPPQPPVKD PNRQGKMTNQ LQFLQKVLLK SLWRHHFAWP FHEPVDAAKL SLPDYHKIIK
NPMDMGTIKR RLENNYYRSA TECMQDFNTM FTNCYIYNKP TDDIVLMAQS LEKAFLQKVA
QMPQDELEMP PPTPRSKPVK PGRKGKVSGG VTTAHQVPAV SQSAYSPPTP ETPDSILSTP
PQTLMSKSLP PVLPIEQSIP TITSLPPTQP TAKKKGVKRK ADTTTPTTVA MPIMSTMGVS
GISLGMGDGH NSPLTLTSLG VDHNSGLGMN QGLSMSQGMG LGLGMGMGMG MGMGMGRGTV
MMGTKAAGNS RRGASGRPIK PPKKDLPDSI LPTPVRRSKL SPQLRYCNGV LKELLSKKHA
AYAWPFYKPV DASTLGLHDY HDIIKQPMDL SSIKRKMDGR EYRDAQQFSA DVRLMFSNCY
KYNPPDHDVV AMARKLQDVF EFCFAKMPDE APAPPSSSSS SSSSSSSSES ELSSESEESE
SSPSSDSEEE RANRLAELQE QLKAVHEQLT ALSQGPIVKP KKKKEKKDKK KKKKVEKEKH
RRVEEEPPPP PPVKPVKAPK ITKTPKAKTN RAVACPVIPV KKAPSKKNNK SKAKKSGMMF
SMPPPIHDPI VSHFDSDEEE ETAPMSYDEK RQLSLDINKL PGEKLGRVVY IIQSREPSLR
DTNPEEIEID FETLKPSTLR ELERYVMTCL RKKPRKPYAS KTNSAGKSRE ELALEKQLEL
ERRLMDVSGQ LNSGKKPTKT KPEKPATDTH IQPSRLSASS SSSDSSSSSS SSSSSDTSES
DSG
//
