ID A0A2U9IEQ4_9CREN Unreviewed; 154 AA.
AC A0A2U9IEQ4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Riboflavin synthase {ECO:0000256|ARBA:ARBA00013950, ECO:0000256|PIRNR:PIRNR015750};
DE EC=2.5.1.9 {ECO:0000256|ARBA:ARBA00012827, ECO:0000256|PIRNR:PIRNR015750};
GN ORFNames=DFR85_07875 {ECO:0000313|EMBL:AWR94523.1};
OS Acidianus brierleyi.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=41673 {ECO:0000313|EMBL:AWR94523.1, ECO:0000313|Proteomes:UP000248044};
RN [1] {ECO:0000313|EMBL:AWR94523.1, ECO:0000313|Proteomes:UP000248044}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1651 {ECO:0000313|EMBL:AWR94523.1,
RC ECO:0000313|Proteomes:UP000248044};
RA Counts J.A., Kelly R.M.;
RT "Complete Genome Sequences of Extremely Thermoacidophilic, Metal-Mobilizing
RT Type-Strain Members of the Archaeal Family Sulfolobaceae: Acidianus
RT brierleyi DSM-1651T, Acidianus sulfidivorans DSM-18786T, Metallosphaera
RT hakonensis DSM-7519T, and Metallosphaera prunae DSM-10039T.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-
CC ribitylamino)uracil + riboflavin; Xref=Rhea:RHEA:20772,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:57986,
CC ChEBI:CHEBI:58201; EC=2.5.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000968,
CC ECO:0000256|PIRNR:PIRNR015750};
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin
CC from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-
CC ribitylamino)uracil: step 2/2. {ECO:0000256|ARBA:ARBA00004887}.
CC -!- SIMILARITY: Belongs to the DMRL synthase family.
CC {ECO:0000256|ARBA:ARBA00007424, ECO:0000256|PIRNR:PIRNR015750}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP029289; AWR94523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9IEQ4; -.
DR KEGG; abri:DFR85_07875; -.
DR OrthoDB; 23911at2157; -.
DR UniPathway; UPA00275; UER00405.
DR Proteomes; UP000248044; Chromosome.
DR GO; GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
DR GO; GO:0004746; F:riboflavin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09210; Riboflavin_synthase_archaeal; 1.
DR Gene3D; 3.40.50.960; Lumazine/riboflavin synthase; 1.
DR InterPro; IPR002180; LS/RS.
DR InterPro; IPR036467; LS/RS_sf.
DR InterPro; IPR006399; Ribfl_synth_arc.
DR NCBIfam; TIGR01506; ribC_arch; 1.
DR Pfam; PF00885; DMRL_synthase; 1.
DR PIRSF; PIRSF015750; Ribfl_synth_arc; 1.
DR SUPFAM; SSF52121; Lumazine synthase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248044};
KW Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619,
KW ECO:0000256|PIRNR:PIRNR015750};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR015750}.
SQ SEQUENCE 154 AA; 17014 MW; 7A68B729291842B8 CRC64;
MRKYGIVDTT FSRIDMGNIA IKTIKKEDLD SEVIRYTVPG IKDTPVAAKK LIEKGCDGVI
TLGWVGKTML DKYSYLAASI GLITVQILTS KHIIDVTIHE DEADDIDKLK EIAIDRVVKH
SKNLVKLIRD GENSLTPFAG KGLRQGYKDA GPID
//
