ID A0A2U9P293_STRAS Unreviewed; 736 AA.
AC A0A2U9P293;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=DMT42_16720 {ECO:0000313|EMBL:AWT43799.1};
OS Streptomyces actuosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1885 {ECO:0000313|EMBL:AWT43799.1, ECO:0000313|Proteomes:UP000247634};
RN [1] {ECO:0000313|EMBL:AWT43799.1, ECO:0000313|Proteomes:UP000247634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25421 {ECO:0000313|EMBL:AWT43799.1,
RC ECO:0000313|Proteomes:UP000247634};
RA Liu W., Sun F., Hu Y.;
RT "The complete genome sequence of a nosiheptide producer Streptomyces
RT actuosus ATCC 25421: deducing the ability of producing a new class III
RT lantibiotics.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP029788; AWT43799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9P293; -.
DR KEGG; sact:DMT42_16720; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000247634; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000247634};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..328
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 736 AA; 75988 MW; DC525C86A4D7B1E7 CRC64;
MATFLYKLGR LAFRRRHFVA LIWVALLTLA GVGAASAPAA GNSSFSIPGT EAQKAFDLLE
QRFPGMSADG ATARVVFQAP DGQKITDAGN KATVEKTVKE LSDGSEVASV ADPFTGKAVS
KDGTIAYASV KYEVSGMELQ DATKDALKDS AQHARDAGLT VEIGGDALSA VPETGATEVI
GIAIAAVVLV ITFGSLLAAG LPLLTALIGV GIGVSTITAL ASTLDLGSTT STLATMIGLA
VGIDYALFIV SRYRAELAEG REREEAAGRA VGTAGSAVVF AGLTVVIALV GLSVVNIPML
TKMGVAAAGT VAVAVLIALT MIPALLGYAG RKVKPAGQKS KLLGGARAER KTASGKPNMG
TRWASFVVRR PVAVLLLGVV GLGAAAVPAA SLELGLPDDG SQPVSTTQRR AYDLLSEGFG
PGFNGPLMVV VDAKGAADPK AAVASVGDEI KGMKDVVTVT PAAFNKDGDT ATITVIPGSK
PSSTTTEDLV HGIRDAGAGI KAKTDAELLV TGTTAMNIDV SQKLNDALIP YLVLVVGLAF
LLLIVVFRSI LVPLKAALGF LLSVMAALGA VVAVFQWGWL SGLLGVEETG PVMSMMPIFM
VGVVFGLAMD YEVFLVTRMR EAHVHGEKPS QAVVTGFRHG ARVVTAAAVI MMAVFAGFIG
SSESMIKMIG FGLAIAVFFD AFIVRMAIVP AVLALLGKRA WWLPKWLDRA LPNVDVEGEG
LRTHPTGDEN RELVRA
//
