ID A0A2U9R3S2_PICKU Unreviewed; 1228 AA.
AC A0A2U9R3S2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Nuclear protein STH1/NPS1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=C5L36_0B12210 {ECO:0000313|EMBL:AWU75992.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:AWU75992.1, ECO:0000313|Proteomes:UP000249293};
RN [1] {ECO:0000313|EMBL:AWU75992.1, ECO:0000313|Proteomes:UP000249293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS573 {ECO:0000313|EMBL:AWU75992.1,
RC ECO:0000313|Proteomes:UP000249293};
RA Douglass A.P., Offei B., Braun-Galleani S., Coughlan A.Y., Martos A.,
RA Ortiz-Merino R.A., Byrne K.P., Wolfe K.H.;
RT "Population genomics shows no distinction between pathogenic Candida krusei
RT and environmental Pichia kudriavzevii: One species, four names.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CP028774; AWU75992.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9R3S2; -.
DR STRING; 4909.A0A2U9R3S2; -.
DR VEuPathDB; FungiDB:C5L36_0B12210; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000249293; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17996; DEXHc_SMARCA2_SMARCA4; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029295; SnAC.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR10799:SF1012; NUCLEAR PROTEIN STH1_NPS1; 1.
DR PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF14619; SnAC; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM01314; SnAC; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51204; HSA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000249293};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 257..338
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 454..619
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 767..923
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1138..1208
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 386..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 142470 MW; 1F1E2C5EB93E2EC9 CRC64;
MNTADSLIQR LVECRNTADY TPILEKLAQY DESVRRSNAN KNDLDESWSK NTEQVDLELL
RKQVLGLQLL AKDIDLPTEL ALEYLKNDDD SIKKQLNDTK KSSINDVSIP LPLDDYDSKA
EMLGIIPNKP KVDPRFHSVG SPELEDLVKL KIDSRINQLE SLSSNLGSYD FSKFENDLNY
SNEEILDNVD ELKIDALVEL KSLKLLPLQK QLRNHLLIKV ATNTIYNDES LNNYSVFKTW
KRTYCVHPKQ KVVQTAKLAE KLQQQQQFER EKLIESLHNE KVQLYIETAN KTQNNIASNQ
MRRFQLGKSI HKFHQECERD ESKKFERNAK QRLQALKAND EEAYIKLLDQ TKDKRITHLL
KQTNSFLDSL ANAVKVQQNE TKILTQIEKG MNPSKDSKTE EEEEETEKES ETKEKKVDYY
EVAHHIKEKV EKQPSILVGG TLKEYQIKGL EWMVSLYNNH LNGILADEMG LGKTIQSIAL
ITYLIEKKSE SGKFLIIVPL STITNWTLEF EQWAPSLKTI VYKGSQQQRR DLQHQIRMAD
FQVLLTTYEY VIRDRPLLSK FKWAHMLIDE GHRLKNADSK LFQTLTNYYT TRNRLILTGT
PLQNSLPELW ALLNFILPKV FNSVKSFDEW FNTPFANTGH QEKLELSEEE SLLIIRRLHK
VLRPFLLRRL KKDVAKDLPD KVEKVIKCKF SNLQSHIYKQ LLTHNALFIG EGQIGATKSG
LKGLNNKIMQ LRKACNHPFV FEEVENLVNP DRLTTDLIWR CSGKFELLDR ILPKLRATGH
RVLIFFQMTQ VMDIMEDFLR FKNLKYMRLD GSTKADDRQS MLKDFNAPDS EYFCFLLSTR
AGGLGLNLQS ADTVIIFDTD WNPHQDLQAQ DRAHRIGQKN EVRILRLITS ESVEEVILER
AHQKLDIDGK VIQAGKFDNK SSAEEQEAYL KSLLEKEKLK GDDAENDNFD DAEINEILAR
DENEMETFEK LDMDRAREDT VRGTPRLMEE DEVPEVLKED MSQHVDVREE ASGRRVTKKV
IYDDGLTEEQ WLQAMDDEND SVEAAVERKR QRLAKMRNKN EETTDEGLNN DDFKGSDSDE
EVYADDVPNR KRQRLSRGST PKESSVKKNQ KKEAKPLPEW IQRGYELLDS LERLTDEDGN
DISSLFIKLP SRKYYADYYK IIPHPVSLNQ VRKQLDTKKL ANWDAFIGEL KQMVANAHVY
NEEGSYVAKA ADILGKRMDE MVSQWDIS
//
