ID A0A2V0NN30_9CHLO Unreviewed; 997 AA.
AC A0A2V0NN30;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=DNA mismatch repair protein {ECO:0000313|EMBL:GBF88958.1};
GN ORFNames=Rsub_01457 {ECO:0000313|EMBL:GBF88958.1};
OS Raphidocelis subcapitata.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Selenastraceae; Raphidocelis.
OX NCBI_TaxID=307507 {ECO:0000313|EMBL:GBF88958.1, ECO:0000313|Proteomes:UP000247498};
RN [1] {ECO:0000313|EMBL:GBF88958.1, ECO:0000313|Proteomes:UP000247498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-35 {ECO:0000313|EMBL:GBF88958.1,
RC ECO:0000313|Proteomes:UP000247498};
RX PubMed=29795299; DOI=10.1038/s41598-018-26331-6;
RA Suzuki S., Yamaguchi H., Nakajima N., Kawachi M.;
RT "Raphidocelis subcapitata (=Pseudokirchneriella subcapitata) provides an
RT insight into genome evolution and environmental adaptations in the
RT Sphaeropleales.";
RL Sci. Rep. 8:8058-8058(2018).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBF88958.1}.
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DR EMBL; BDRX01000007; GBF88958.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V0NN30; -.
DR STRING; 307507.A0A2V0NN30; -.
DR InParanoid; A0A2V0NN30; -.
DR Proteomes; UP000247498; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000247498}.
FT DOMAIN 778..794
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 211..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 499..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 907..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 105039 MW; 7CBD3CB9D11EDA6B CRC64;
MAGQASTAAP ELALDAQSQT GFVKWFHTLD QDPKLVRFFD RKGFYSVHGE NALFVARTFY
RTTAVVKYLG GGGAGAAAGG TPPPGGASGL PSVTLSRSLY ESVLKELLLE GGQHSVELWE
GYGAHWKAVR TASPGRLSAF EEELFRGGEA GDAPLVAAVS LGYSEGQRVV GAAFLDPGAR
RLGACQFVDD EHFCGLEALL VQLGAREVVV QKGPEPGGDK AGGDKGGGGG GGAVGAAGAS
ADRRRLADVL DRVGAMGSER PRALFASKHL EQDLGKLLKS ETVEQHRDVL ERPQACAALA
ALLAFSEVGA DPSGLGKYSL SLHDPGRFMR LDAAAQRALH VFPARGDASS SFSLYGLMCK
ARTSMGKRRL KVWLKQPLVS AAEIDARLDV VEALAADAAL RDAVRDALRG MPDIERLTRK
LEARRISLAE LCQLYRASSA LPRLEDALRC HEGHAAALLT ERFAAPLAAA HDETHLSKFE
MLLEASIDLD RVPEEYVISA AYDSRLQALR EQKDAVEDEI TGVAQAAAKD LGLVLDKTLK
LEWHKAANTR TRCMRITQKE EKAVRGRLQS KYKLLETRKD GTKFTNAALR DAAERLGAAA
GKYEDLQKDL VAQVVAVAHT FVEVWEGVIG IIAELDVLAG FAELACGDPT RPYVRPTILG
EGQPEEVALE GCRHPCVEAQ EGVAFVANDC RLVKGSSWFT IVTGPNMGGK STFIRQVGVA
VLMAQVGCFV PCASARITPR DAIFARVGAG DCQLRGVSTF MAEMLESAAI LKGATSRSLV
IIDELGRGTS TYDGFGLAWA IGEYIMHTIG APTLFATHFH ELTDITGPGG VANLHVGTRI
EPDTGKLTML YEIRQGACDQ SFGIHVAESA AFPPSVVAAA KRKLEELEAA AAGGGGGGGD
GDGAGGVAGK KRAREGEGGG EEAMDVDGRG GARARASDQD PVASEAEAAA RRFLSEFAAM
PAEKLRGAGG AEAAAALVAG LEAAAGSNPL IRGVLDC
//
