ID A0A2V0PCH0_9CHLO Unreviewed; 1549 AA.
AC A0A2V0PCH0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=Rsub_10090 {ECO:0000313|EMBL:GBF97229.1};
OS Raphidocelis subcapitata.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Selenastraceae; Raphidocelis.
OX NCBI_TaxID=307507 {ECO:0000313|EMBL:GBF97229.1, ECO:0000313|Proteomes:UP000247498};
RN [1] {ECO:0000313|EMBL:GBF97229.1, ECO:0000313|Proteomes:UP000247498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-35 {ECO:0000313|EMBL:GBF97229.1,
RC ECO:0000313|Proteomes:UP000247498};
RX PubMed=29795299; DOI=10.1038/s41598-018-26331-6;
RA Suzuki S., Yamaguchi H., Nakajima N., Kawachi M.;
RT "Raphidocelis subcapitata (=Pseudokirchneriella subcapitata) provides an
RT insight into genome evolution and environmental adaptations in the
RT Sphaeropleales.";
RL Sci. Rep. 8:8058-8058(2018).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBF97229.1}.
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DR EMBL; BDRX01000094; GBF97229.1; -; Genomic_DNA.
DR STRING; 307507.A0A2V0PCH0; -.
DR InParanoid; A0A2V0PCH0; -.
DR Proteomes; UP000247498; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:GBF97229.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000247498};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 978..1143
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1251..1533
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 310..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1549 AA; 159985 MW; 4D07F4D2309C1789 CRC64;
MLLFASAAER AAPGGGGGGG CARDLGALLP AVAAAVEGLQ PRTLQVLGGS SSRMGIHDIQ
AAQREDASTT RLFRNLWLQA ALHGLVDPTR PRAPVLAPRL WGHDGADAGD VEWQDAAGRV
AGVTPLLVVG TDSYLEADMV ERLKVELGDQ LNAAGRLAER GAAAAALCRL VDSGAPGGAP
PPAPGEKVLQ AFLLAVAMSE LCRAALAPLP DLDAEPIVAC PVSTTLGYLK GLLPAGAASD
WVAAIARRAF GLYLARLVAL RSLQQAAALG DGARGGARAG PASAAAAGAA PALAYAEQLA
RALIAHLGDG GGDGDARAAP RRRRRRRGGG GGAPDLGGIA DSMLEQLLVS FPALLHSRPV
YAALLAQLQR EEGDSGLGAL AASSHGAVWE RTQAVVRAAA QAAPATTEAM VHSFLGSGGV
GGGRARGAGR GGLGGLGALG SGSFGARHRG PLAGAGARGG DGGLGEEAAA RQAALRRAAD
LLRVCGDARE ARAGDADGAS GGPDGGAYQG TLALSRKLHY SGYARGLINQ ALTAVQGSSD
GGGGGARRGA SPGAESSGSS GLGGAAAQAA AIKEVASELS AALNADLDGH SRAAAALAAA
PDDALLCATA LLASQPLLAG AQDWGAGEGD DAGEGSDREA AALDALRGEG LRLLRALCAA
PLRRLTPDAT QLATFAWTWL STESPGMLVP LVCNLAGAWV WTVDQRLGLF SGQPRGPAAS
AGGASAGDAA AGDAAAAVAA AAAADQEGEG EEAPADANDP DVLRAIAAHD VWLSYLAELW
TVLRRRGGAV GAAARAQFAR LLHASLAEPA ALSAHAASLG PRFRLLQLAV NFARDLARDS
GGAPPAAALL LFDQSLRAAL FWFAAPPGYY AAHTRGEARE QLASLEGFSQ LLASFPPGGW
PTYSPTAAAA AGAGAAPAEH PVWRVAAPRV GGYVRLLQLL LGEEVKRVQV WNEPLEDAPI
TGLPEKAPWD ELVPLAWEVD PSLALALRAR YPTVAGIARP LEALVLQHAE EPRVQREPDA
ALVLATARSP ARDALLPLLA AWAPGRATLG LQLLCGPAGR EAAVRSYSVK CLLNERPEEV
VFFLPQLVQL LRGDDGVVAG FFTAAASHSD LFAHRLIWAL MSEQRPPEEA FAPEVKRSGW
QPPKDTGLWD ISTRIKGEIE GGMSPEQKEY WEAEGGYFDQ VTALSGYLYK FSKDERRGKL
VEALTGFKPP RDDLYMPTNP EARIVSHIPS SGACMQSAAK VPILVAFNVE RPPPASASAG
GAAPAAAPAP PHGPRASHGG PPRVSAKMAA IFKVGDDIRQ DVLAIQVITL LHAAFTRAGL
GLYLRPYGCM PTGYECGIIE CVPNTRSRAA LGELSDRGLY DIFCAEFGAP GSAAFESARH
NFIVSEAAYA VASFLLQAKD RHNGNIMLDD EGHIVHIDFG FILEISPGGN LGFESAAFKL
SHEMAQLLDP GGRRASPQFR LFEEAVVRAY IAARTVAEPI ISSVALMAES GLPCFGRGAP
VANLRRRFHL ELSDSQAAAW MRATVNDAYD KWTTGFYDYI QSLQNKIPY
//
