ID A0A2V0PR05_9CHLO Unreviewed; 3943 AA.
AC A0A2V0PR05;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=Rsub_13271 {ECO:0000313|EMBL:GBG00521.1};
OS Raphidocelis subcapitata.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Selenastraceae; Raphidocelis.
OX NCBI_TaxID=307507 {ECO:0000313|EMBL:GBG00521.1, ECO:0000313|Proteomes:UP000247498};
RN [1] {ECO:0000313|EMBL:GBG00521.1, ECO:0000313|Proteomes:UP000247498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-35 {ECO:0000313|EMBL:GBG00521.1,
RC ECO:0000313|Proteomes:UP000247498};
RX PubMed=29795299; DOI=10.1038/s41598-018-26331-6;
RA Suzuki S., Yamaguchi H., Nakajima N., Kawachi M.;
RT "Raphidocelis subcapitata (=Pseudokirchneriella subcapitata) provides an
RT insight into genome evolution and environmental adaptations in the
RT Sphaeropleales.";
RL Sci. Rep. 8:8058-8058(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBG00521.1}.
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DR EMBL; BDRX01000238; GBG00521.1; -; Genomic_DNA.
DR STRING; 307507.A0A2V0PR05; -.
DR InParanoid; A0A2V0PR05; -.
DR Proteomes; UP000247498; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000247498};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2562..3414
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3554..3870
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3911..3943
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 365..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2127..2160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2432..2464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2650..2670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3419..3456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3834..3863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3943 AA; 393153 MW; A6D30C5B7CEA7AAB CRC64;
MESQIAALRD QLLADKGQKT RKEGIKRLEA LLDSEEALAQ LDRRTGRIWP ENNIPLASWP
GLLDAYLKHL KKGGDLSAKR AGGDVGGVKL LRRIIAVADD EERCGPNCCH IARRVALVFA
YVCEALSSRD AFRGGAGAEL ATLLQKQLLP NAAYCQRARV AHFTQILDAV MDHVDDLIRS
NEAPRPPAGA RAGPSLHVAP SEELQRLTGL VLALLQQMPG TMPLVAAGEV LAFLGHVVDW
MSEQREYSKT ALNVMQALQQ LLLAYGHSLR GPPLSTVARA VQPYLRRAWR EARLPRLKEA
LAAYCRAALR LGAMQALGPV ALSEVQQLMA HDLGAPGFAW ETEGGQPAAP LARHHAALAA
AAGDVNHYSQ QQHERAAAAA PARGQPDAAA AGGGGGGGAA ARRRGARSAS ASDGRGSGGG
GSGGGAGSGG GSDGSDEKAL ELPRKRARAA APMSRLVDAC CDRPAHWGPP MAALLRQHGA
AALCGGAEGE GAGGCCYAVL LLRGVARRLP ALLAAAAAEA AAAARGAPGA GAAAAAGPVA
AGAGVLGSQK LWDDLLWLLR VARELALAWP AQLHPASEGL APACPPAGPD ERREQLRLRQ
RLLHRQASEA GRLWQQVWDA AVAYAAECRG WEAAVAPPAA AAAAWHLPAA RAAAAWLLQA
QLGARLLAGG TRGPDRAALA ARLRRLWAAP LGDAEAALLA TLAAAGHGSG GAGSGALPPE
LAVACIDTIA RGGPGGGSAL ALAPSSALGP RPPVLSALHA LLSAPPALSG AALHELRCED
AAAAAADRLG GRAGPRAAAV NGGVLAARLV AQHDAWEAGL APPSLLQSPR IAADVTAAFA
GGSPVAAALA AAGSCGFDGG GGGGGGWCSA PGLASPGCWA HCDWWAPDAE AAIAERQLSG
LEPAEQLLSL RLEAARASEL ARRLAAGDAG RGGGGGGGED DGGGGGGGAA DGGDWWEAAC
GAARRLIEAL SDLGGKLQPP PPQLPIGAAD VAAEAAAACA TAAAAAVEAA RLHLLPLLQA
ATAALALCSA AALRPPPPPR AAEAAAAAAG AGGGPAAAAA SLPLDPMEID GAPDGAPPAA
AAPPASDPAS LLGPRLADAA AAALARAGPA LVSLLSDGAA FYPGAPLLRQ LELLAAELSR
LARLRRDVLA ALGAALAGVA AGIEAAARAD AVAAAQAAEA ATKYIRSRTF GSSERDFDDD
LDLGRVPSFK RPASTPAVLT THPSTNAAAA AQATQAAAAA AAAAAAAAPG SAAAHALAAA
SGGLFSGRTY GGARGAGGGA LRVLRALAAA DGGLVAGAVL RHWKLVHGLT GLAPGEQLLE
DMAEAMVAAV CEDAWLHVRS AAMMLDSQHG ILRSKNPTPA TLTAALTLVG RLASAAAASG
ASELLLHSPA ALEARLAGGG DGSQAWLDHR AAGGGGAAAG GGEGDEAPIL SYLTAVVEVA
VGMVANLEME DGATGLPHDP SPDHSRLQQG RTLAALALVE PSLIRPGGEL ANLSVRLPGL
LLDRSYSVRA AAGQLVCSLL LVSNEALLEA KLLPHIPLAL PRQLRPPPSA VPEGLTWAEA
GARVASAAGA ATGDAAGGGG GGGGAAAALA PYWETGVLQL ADAALAAPNL EGRALLLLCG
HAATACAAAE AGGAHDLRIL PLAAAAAELL AARSRYAPGR TECALYHAPG LAWEWLVVRG
LDLSPLLEAR HVLAAPLDAT PSAGADVDSE ISESAFAALF SPALLPPLLL RPDLPGLSSL
SGLLGHASAS ELLEARWSEA VGPVTALGAL PQYLAAATAA LQSEGLAALV PAARQAALAS
AQMRPIAVAM LRSAALVPGA PPPSEAVAAA ARGGGGGDGA ADADALLAAV PGAGGEPQLP
SLPPQLVAAR IKAIMSQVGR FEATTLRAPH LPGVLLALHR HLLAAAAPSH RAARLGALHA
ALLLLGDRAA VTGTAHYVAS ILLQLVPEPE AQPAACALLE ALLRRVAAVA ARSASADARG
TAATLLGALL QDAAGALVAA LEGGLARRRA AAATAAAQGV RAAAAAGSGP PPSDPVVALL
AGLLPSLPGG ALRPYLRSLD PLPALPALAR AAAALADARE GLTLDAELRA FAARAPGMPP
AARRRALAAL RAGLEEREGE LLAPPPDAAA AAAAGTDPNA GPPCTDEGGA AGGGGEAGAG
VAGRLRPEVA DAAWSLARLG AELDDAGLSG LAARLLAAAG PLPPEVISCG RTADGGRDAA
VYASAAGDDE SAAGAAGGAA AAARRGRGDA SPTGDPRRDA MLFDSLLILG GRLAGPEPDV
IAAAQSAARA LLARPGGAAA LAPLQDALER GRAAEGPDGT AAAGRALVAC YLAGLKPRSG
GGAAGGGDDG APPAPAPPAA AAAAAAAAAD PALWRPPPVG EPFAAWICRL SPALLAACSR
DEELRLLAPA AALLPELAEA LLPHALRHLV GGGGSGGDPD GSDGGGSGGG GGDGDGGGTE
GLPPARAREE LGRAVEAALA AGAAAVAGAD GGGGGGSEGS SGGGGGGLQD VKRALRVLLR
GLEFLRGVHR DGMLAAKGRP PLDRLHPYHW PTVYALRVDY LTVARAAEAC GAHFAALLYL
ERACEKRYGR AALPRAAALA EAAERAGGGG VGAGGGGCGG GAAPAAAAAQ GPSLLERLLP
AATQAQAQAA ARAAAAPQGP PPGRGARGAA AAARAAAAAA AASAQAAASS SEADAELSEV
ESLLLSAYER INDPDGVYAI AALLDSARGR LALQRHEGRW SEVLAATDER LQHPAALAGG
GSGGSGGGGG GTEAELLRAL DSMGCRHTAR QYLRAAGDTV TRGATGGGAV AELEAQLAWQ
LGDWSPTPQG GGGGPGCAGG IESTASMAAP EAAAAGQSAD GAGVGGGGGF HSAVLRSLQL
LRAGDGGAFA SALSEARHSA VCGLATSGDE SAVTVNRSLV RLQMLELLRR GWALRWPTHG
AAAAAQVGGA PAAAARGGGA RALVPEGTDE LLARLLGPLG AGAGGASEGG GAGGSAAAAA
AAGVPSSVLL LRRGDYRQAE QLLGLQACLV QLLGRPDALA VTLEAAAAIA RRSGRLDAAD
AALSRVRALV AAAAAADGAA DGAGAAGGGA AAGWWRRMAR PQAPWLLESV KLMWDRGQPA
AALRELHGLI AAVEASASAA ASPASPPASD AAAAPEPHAH LARMLSLAGK WSAATQHGGG
RTATVMQLMV RGAEELTDSG AGRGHLACQV FFRLAAFADE RYKQTQQQMS SPEWRTQQAV
IAAKRRQVEA WQSRLDGPGL NEATRRHCLV SISALQRVIG ADEAATQQLQ DLATKCLHIA
LQNYGRALQA GGEHDLQARG GGGRAVYRLC QLWLALSDDA AVNRRVGEVV EAAPSAKFVP
LVYQIASRMS AKAAAGQQGE AQRSFQKVLA RALERMALDH PYHTLYSLIA LRNGNLGRDG
QPVAPAPAPG GGPGGGGGGG GGGGGGGGGG QPLARQGFDN DKVAAAAALL ARLAKNPRRA
ELLRQMEALV ACFVELAATK FPSRQGGGAP PDGWPFPAAL KRRLQSLTLV PVPTAPLPLD
PSGAYAGVPV LAELGARLGH AGGINAPKVL AATDSAGVAH RMLVKSGNDD LRQDAVMQQF
FGLINTLLAA TPAAAARRLG MGTYRVVPIS PAAGLVQWVE NTVPMADYLA GRTRQGGAHA
RYRGRGEWSW FDCYTRMSKA PPDQLLPSFL ECLSKFPPVF HNFFLEAFRA PAAWFEARAG
FTRSIAVSSM AGYVIGLGDR HLGNMLLDRR SAGVLQIDLG VAFEQGAFLN TPETVPFRLT
RDVVDGMGAF GVEGPMRRCC EETLRVLRRH REALLTVVEV VLHDPLYRWQ MSPVRAQRRQ
QDPAAARGAD GSDGGGGAGA ATGTGAGATG TGAGATAGGG ATGEAIGNAD AARAVLRVKQ
KLEGVAGGEG EPLGVAAQVD TLLAEAQDPE LLCRMFVGWS AWM
//
