ID A0A2V1AKK0_9ASCO Unreviewed; 351 AA.
AC A0A2V1AKK0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=CXQ85_001127 {ECO:0000313|EMBL:PVH18837.1};
OS [Candida] haemuloni.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=45357 {ECO:0000313|EMBL:PVH18837.1, ECO:0000313|Proteomes:UP000244309};
RN [1] {ECO:0000313|EMBL:PVH18837.1, ECO:0000313|Proteomes:UP000244309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B11899 {ECO:0000313|EMBL:PVH18837.1,
RC ECO:0000313|Proteomes:UP000244309};
RA Chow N.A., Gade L., Batra D., Rowe L.A., Ben-Ami R., Loparev V.N.,
RA Litvintseva A.P.;
RT "Genome Sequence of a Multidrug-Resistant Candida haemulonii Isolate from a
RT Patient with Chronic Leg Ulcers in Israel.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVH18837.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PKFO01000001; PVH18837.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V1AKK0; -.
DR STRING; 45357.A0A2V1AKK0; -.
DR EnsemblFungi; CXQ85_001127-t46_1; CXQ85_001127-t46_1-p1; CXQ85_001127.
DR VEuPathDB; FungiDB:CXQ85_001127; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000244309; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000244309};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..351
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015854287"
FT DOMAIN 9..278
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 351 AA; 38596 MW; FF56B75A75CC9B69 CRC64;
MSTLNSVLLV GGAGFLGLHL VQQFYDHCPN TAIHVFDIRP IPDNLSKYFT FDTSKIHFHQ
GDLTSEDDIE KAIAASGCEV IVHSASPMHG LGQEIYQKVN VVGTQALLKV AKRTPVKSLI
YTSSAGVIFN GQNVYNADES WPYPEVHMDG YNETKAIAET AVMEANDPEK LVTVCLRPAG
IFGPGDRQLV PGLRTAARLG QSKFQLGDNN NLFDWSYAGN VADAHVIAAQ KSLDPVASKE
IGGETFFVTN DAPTYFWTLA RTVWKADGHI DKYNIVLSRP IAIAAGYLSS FFSSLLKKEP
GLTAFRARVT CATRYHDITK AKTLLGYKPA VSLEEGIKHT LDWVYETHEE K
//
