ID   A0A2V1ALV7_9ASCO        Unreviewed;       758 AA.
AC   A0A2V1ALV7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
GN   ORFNames=CXQ85_001043 {ECO:0000313|EMBL:PVH18755.1};
OS   [Candida] haemuloni.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC   Candida/Metschnikowiaceae.
OX   NCBI_TaxID=45357 {ECO:0000313|EMBL:PVH18755.1, ECO:0000313|Proteomes:UP000244309};
RN   [1] {ECO:0000313|EMBL:PVH18755.1, ECO:0000313|Proteomes:UP000244309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B11899 {ECO:0000313|EMBL:PVH18755.1,
RC   ECO:0000313|Proteomes:UP000244309};
RA   Chow N.A., Gade L., Batra D., Rowe L.A., Ben-Ami R., Loparev V.N.,
RA   Litvintseva A.P.;
RT   "Genome Sequence of a Multidrug-Resistant Candida haemulonii Isolate from a
RT   Patient with Chronic Leg Ulcers in Israel.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVH18755.1}.
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DR   EMBL; PKFO01000001; PVH18755.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V1ALV7; -.
DR   STRING; 45357.A0A2V1ALV7; -.
DR   EnsemblFungi; CXQ85_001043-t46_1; CXQ85_001043-t46_1-p1; CXQ85_001043.
DR   VEuPathDB; FungiDB:CXQ85_001043; -.
DR   OrthoDB; 6504at2759; -.
DR   Proteomes; UP000244309; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR   PANTHER; PTHR32468:SF0; K(+)_H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244309};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        85..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        118..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        224..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        266..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        315..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        343..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        376..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          33..422
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   758 AA;  83998 MW;  1717B25DF6A038AF CRC64;
     MVSTSSVAGI VSGRNPLEYV SSSPYTLFLF QAVFILFLCQ VLHWPLRKLQ QPKVIAEVVA
     GILLGPTVLG RIPNFTETVF PEESIPGMTL IANVGIIMFL FIVGLEVDLH YIKKNLKVAV
     SVGLINMAIP FGLGCAISVG LYNEYRTDPG MESIEFTTYM VFVAVALCIT AFPVLARILV
     ELNLIGDRVG TIVLAAGIMN DLTGWILLAL VVTLSNADNG INTLYILLLT LAWFLLLAFP
     VRLALRWYLK RFTNELATGE PSQLSMVIII AMVFISAFYT DIIGVHPIFG AFMVGVLVPR
     DNGYVIKITE KLEDMVHIVM IPIYFALAGL NVNLGDLDRG IDWAYVVGVI SLAMIGKVAG
     GLIAAKMNGL FWRESLTVGV LMSCKGIVEI VVLNVGLNAN IISRRVYSMF IVMTLVTTFL
     TTPLTLLSYP VSYRESVARH RGAIKKDTDT EGELLGSPSE LSIKNLYRFK ITDILLLLRK
     IDTLPHVLAL LKDLTYDDFD YDVKAIHLRA FSSRTSHLLE ASSAAPETFE SSPTDLTNSQ
     SILSIVKAFS SMLDVHFSSK SILASQRNYA TAINDHITGP ANLLLTSYTV KSILDLTEEE
     NDFDMSYRYI LENCECHMAI LLTTEPTRTD RESTVRMVLE HDNFMSSTDL LSLYLVAQLA
     KVHRNVHIYV RSNMTGTKDL EEQFDEYVKS SGPDVSLSVS HFREFSDISG EVKHDPALAG
     DVFVVSHEYL ESEVRDELLR FTMREEVELL AVKAATSG
//