ID A0A2V1BYI5_9HELO Unreviewed; 1294 AA.
AC A0A2V1BYI5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN ORFNames=DL98DRAFT_516758 {ECO:0000313|EMBL:PVH78429.1};
OS Cadophora sp. DSE1049.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiales incertae sedis; Cadophora.
OX NCBI_TaxID=1485229 {ECO:0000313|EMBL:PVH78429.1, ECO:0000313|Proteomes:UP000244409};
RN [1] {ECO:0000313|EMBL:PVH78429.1, ECO:0000313|Proteomes:UP000244409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSE1049 {ECO:0000313|EMBL:PVH78429.1,
RC ECO:0000313|Proteomes:UP000244409};
RX PubMed=29679020; DOI=10.1038/s41598-018-24686-4;
RA Knapp D.G., Nemeth J.B., Barry K., Hainaut M., Henrissat B., Johnson J.,
RA Kuo A., Lim J.H.P., Lipzen A., Nolan M., Ohm R.A., Tamas L.,
RA Grigoriev I.V., Spatafora J.W., Nagy L.G., Kovacs G.M.;
RT "Comparative genomics provides insights into the lifestyle and reveals
RT functional heterogeneity of dark septate endophytic fungi.";
RL Sci. Rep. 8:6321-6321(2018).
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DR EMBL; KZ804165; PVH78429.1; -; Genomic_DNA.
DR STRING; 1485229.A0A2V1BYI5; -.
DR Proteomes; UP000244409; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR InterPro; IPR032353; AZUL.
DR InterPro; IPR042556; AZUL_sf.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF16558; AZUL; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000244409};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 946..1294
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 149..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1262
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1294 AA; 146888 MW; 78CD5DC5BDAED62B CRC64;
MTRDTHRVHD DREIVSDADI YAALWATAPF PRLPEDAPSE LKNLTVELDD PKRIYGIHRA
RRRHNFQLLV ERYILQIRYG CQSKTCTTTT CFSCRKRVAN GAPVRRYNSA SARTLAIYMA
SQDNPEMGLC HHNSAGRLSA DAPKPYKPKP GLAGQLRTSV VQSSGIKSDG KEAPKEAPKT
VPKNGAFVED LPDVDNNAER KRPAEILDRW AELDLSLLED PDTKDPRSFV QNVFGTMAFK
MIEWLTPRNL AIFSQTQGQE DSHSRLSDTH QQEDATNLQQ YNEKKVTLSA KSDSDHEDTP
EAPKTTNVTQ GHELLSPPSI TPVSKPTASQ DAPNTAMPSD PKPHVNSVAR TAPSSTRRKK
SDSTESQNPK GILSKQQKQT DSAIEPMSSP PTSVPSLPKH KMPRQTLITS PKMKMSEFNT
QVHEIKHITT APIVESFEAP VVKDDDTDRP NRPQEIKEAQ VTLKTNTTAT PDAKPSPTKD
VLLPQSMSSF SIESINFLCD VMQEDNLFEK HLLRPESIEG SSKRIRDAPP FPLSREVILH
KPSSRYKGQW KAFIEQCLFD VLGKSDSLLK SFCDEESEPF DSQTIWYLML RITRVAPSLV
FDCLWNVTGT LFRPPKQLED AYDWAKDHKS YSRKSVSNHD AARVFNICLH ALIAAAPFVS
DTRQMANMSR IRSYGLAMLS REYSSVESVD LCLAYEDAFS NEPAFRLARR LFAAIPTRRR
FTELLDLQRG TRNGEVREPD VLDLVVGSLK FLDLGTTPIL YFTDDERSLH EKRVPTLILD
WARAVMLQEW EGSAEVPNDG PFGGALAMMA AIYKKRKSLI LGDIHFRTEY FAERLDPVAM
PLEWLSYNQN KKTAHLLDHP YLFDPSTLVT YFRAINYSRM NQSYERAHTT GHLVSHFMSE
GSLVTEKYKR DKLHDRLRTA TSEFMVLEIR RTNVLSDTFN AIWRREEREL MRPLKVRLGE
EGGEEGLDSG GVQQEFFRLA IAEALNPDHG TFTIDTRTKM TWFLPGSPEP LWKFELVGMI
VSLAVYNGLT LPVTFPKALY RKLLGEEVTE LHHIADGWPD LANGLTTLLE WDEKDGLVED
VFARTYEFSV EQFGQPVSRE MGESASHWPQ FSELQSNSNP LDAPSVTNEN RNNYVSDYIR
WLTNVSIQPQ FEAFKKGFFS CIDRRSITLF DSDTLQSVVE GIQEIDISEM RRATRYIGWD
ASHRSIRDFW SIVKRYDLSQ KRKLLEFVTA SDRVPVGGMR NLQFTLQRNG IDDGHLPSSY
TCYGILLLPE YSSREVLRDK LAMALENSKG FGFA
//
