ID A0A2V1CPC7_9HELO Unreviewed; 1134 AA.
AC A0A2V1CPC7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=DL98DRAFT_566663 {ECO:0000313|EMBL:PVH87570.1};
OS Cadophora sp. DSE1049.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiales incertae sedis; Cadophora.
OX NCBI_TaxID=1485229 {ECO:0000313|EMBL:PVH87570.1, ECO:0000313|Proteomes:UP000244409};
RN [1] {ECO:0000313|EMBL:PVH87570.1, ECO:0000313|Proteomes:UP000244409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSE1049 {ECO:0000313|EMBL:PVH87570.1,
RC ECO:0000313|Proteomes:UP000244409};
RX PubMed=29679020; DOI=10.1038/s41598-018-24686-4;
RA Knapp D.G., Nemeth J.B., Barry K., Hainaut M., Henrissat B., Johnson J.,
RA Kuo A., Lim J.H.P., Lipzen A., Nolan M., Ohm R.A., Tamas L.,
RA Grigoriev I.V., Spatafora J.W., Nagy L.G., Kovacs G.M.;
RT "Comparative genomics provides insights into the lifestyle and reveals
RT functional heterogeneity of dark septate endophytic fungi.";
RL Sci. Rep. 8:6321-6321(2018).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KZ804112; PVH87570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V1CPC7; -.
DR STRING; 1485229.A0A2V1CPC7; -.
DR Proteomes; UP000244409; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000244409};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 48..321
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 629..1084
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1134 AA; 125484 MW; E7EE7590160B7DA4 CRC64;
MPLFTVQDWI GAAHLGAGQA AKEEEIVTDY ASSIELTVYS VENLLKDLAP FIHADDDLVA
VARGLTLLSR VLARLTVEPS RHTVKYLTDY LCDRLNNTNS LSSFRAGIHE VAYCLTVIVT
WEHFPPGEAI SVASAIFGLS RETRFKDLKP AARQTLYLLV DTLLRSRGEA LLKASTIPQL
VRGLVTIAEF EKTPGCLEVL FNLYTYLSKD WDLEAEEFQA LWGSFSRYWP VTVGGSKEQV
SKPTSEELRN LLLECILSSD SYAKNAIPMC LEKLDTTQDL SATTKNEVLA TLTACVESYS
VPALNTWSTK IWDSLKYEVW NGDVDDFIRS SLKVLHALSS SLSRRSYDWS SLDSPLALYV
VPTAKECKER LQDSKKQFTR RTGEILSVIA SGSPYAFQLV IKEVLPSMNT IWQDLRLGSE
KTLLLGVFNN ILVARLALPD ISNPTATYSA DQAALLTVER QNMAKLGTDF AKFSQNLVDV
YFGAFTDSEV ASRSSPDPTL TVAAIKGLTL LFQIPEYLSI VEQGMIVQKL NELATNPAQD
AEVSQTVVES LQQICSIEPM VFRENTLLDF LQKLPEKIST DSETCSEDLD VVVRYLESLT
EICCTVVCKK EVTTKPPVIA VSSFWHRNFD AMVEKLLIKF TAVMGDSGQL QYASAIVASI
ANAIEKFDKT VNEAHITTKL PIPNDPSTGP YDYIVLALFR EVVVQKVDSN GHLYVGLKPS
STSGELDKLV SMIGKATMLA LRSKLVTPVN NLVLTWNRHY PKEPSAIWSL FTHTGDGLLA
SSQRNLQQGP RDKCLVNILS TSLLAASPPK SKDELRVPAG DVAAAMVRNS LNMPKDTSRT
CLQSTHEILQ LLVNKFGATN ENLEDGTKLF DLLKSLMEES KSASASQSSK AFQTLAYFTA
ASLWAFDPTL EPLVGLMVDG IKSPTYGRKV AQSFRILLAP SPVLTKENFC SVRLLRNSKC
FALAANPLIA LWQAATDKSL KENYLIAISG ILVYMTPTQL DEGIEASRLL PIILEGVTVQ
DEQFAKTAYM KTLFQLAPRH PKIIEEHLDS VLGRVLDRLR NTYHNPSDSS VECRVLAVDV
LILLVKTVKP ALLTQRANKI NSELDAAKDD AAWEVRKKAG DCAMELFNLN DRMK
//
