ID A0A2V1DMV1_9PLEO Unreviewed; 720 AA.
AC A0A2V1DMV1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=DM02DRAFT_436308 {ECO:0000313|EMBL:PVH99265.1};
OS Periconia macrospinosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Periconiaceae; Periconia.
OX NCBI_TaxID=97972 {ECO:0000313|EMBL:PVH99265.1, ECO:0000313|Proteomes:UP000244855};
RN [1] {ECO:0000313|EMBL:PVH99265.1, ECO:0000313|Proteomes:UP000244855}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSE2036 {ECO:0000313|EMBL:PVH99265.1,
RC ECO:0000313|Proteomes:UP000244855};
RX PubMed=29679020; DOI=10.1038/s41598-018-24686-4;
RA Knapp D.G., Nemeth J.B., Barry K., Hainaut M., Henrissat B., Johnson J.,
RA Kuo A., Lim J.H.P., Lipzen A., Nolan M., Ohm R.A., Tamas L.,
RA Grigoriev I.V., Spatafora J.W., Nagy L.G., Kovacs G.M.;
RT "Comparative genomics provides insights into the lifestyle and reveals
RT functional heterogeneity of dark septate endophytic fungi.";
RL Sci. Rep. 8:6321-6321(2018).
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DR EMBL; KZ805395; PVH99265.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V1DMV1; -.
DR STRING; 97972.A0A2V1DMV1; -.
DR Proteomes; UP000244855; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR PANTHER; PTHR13620:SF104; EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000244855}.
FT DOMAIN 336..416
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..636
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 79662 MW; D2A88494688B0E9A CRC64;
MNNRGQVSGE RLPGNASKAT DVSDEGEINE WRLSFRITPQ TAGKRWWSHN LYKDPKGNPV
KVFYSRTKEQ SENLAQRFLD EPVVGFDMEW PVNPKQDRLQ DKIGLIQVAC EDTIALFHIG
VHVGSQSEQI IAPSLRKLIE SPDIAKTGVN ILHADFSRLK KHFGLRPQGA FELSHLHNLV
TFSKKPELLR TKLVKLASQV EEHLGLPLSK GSVRTSNWSQ PLNQQQIDYA AADAYAGFML
FHSMNKKRMA LVPIPPLPIF AERYAPGSNT GALKGALLLH PSNEGGSVLI AKDFFEQAND
DNGEKGLPAH RTPEPTQKRQ KKQTTSEVED PSTFLDMSSR QLFEQLMQRR RELAKDEGMP
AYIIANNDTL EILAVRRPRK HSELLDVKGI GPVKQEKYGS DWLQVISQFV KTENRSKRKP
STHPARPAIT IRSDRTPGTL SAPPPSTNRS NPTPITHSAR SPVTPLPKSE WGPLDLSDLS
DLSNLSDSSE SSYFGSPKPR VPQMHTGLSF NFADVELDDE IPTAGPSSTP TPGPLRNCQA
EFERSSSQHR AQMRQTTTPS SQVSINPPTF NSSQHRAQMR QTTAPSSQVS INPPTLNTSP
ASSSVYYTPS SMPPSKRPAS PHDNPGPSPS GPPPSFSPAN KIFWNKLQAY SRQIARKLPG
HPPNAGPLAS RKTLNMMVLL APTTKEELRQ IPDISEFLQA CNKVGADLLE KVIKFTPAQS
//
