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Database: UniProt
Entry: A0A2V1HLL8_9MICO
LinkDB: A0A2V1HLL8_9MICO
Original site: A0A2V1HLL8_9MICO 
ID   A0A2V1HLL8_9MICO        Unreviewed;       230 AA.
AC   A0A2V1HLL8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:PVZ93345.1};
GN   ORFNames=DDQ50_15300 {ECO:0000313|EMBL:PVZ93345.1};
OS   Amnibacterium flavum.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Amnibacterium.
OX   NCBI_TaxID=2173173 {ECO:0000313|EMBL:PVZ93345.1, ECO:0000313|Proteomes:UP000244893};
RN   [1] {ECO:0000313|EMBL:PVZ93345.1, ECO:0000313|Proteomes:UP000244893}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M8JJ-5 {ECO:0000313|EMBL:PVZ93345.1,
RC   ECO:0000313|Proteomes:UP000244893};
RA   Tuo L.;
RT   "Amnibacterium sp. M8JJ-5, whole genome shotgun sequence.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC       {ECO:0000256|ARBA:ARBA00007871}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVZ93345.1}.
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DR   EMBL; QEOP01000004; PVZ93345.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V1HLL8; -.
DR   OrthoDB; 3208141at2; -.
DR   Proteomes; UP000244893; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 2.30.30.90; -; 1.
DR   Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR   PANTHER; PTHR33238:SF10; IRON-DEPENDENT REPRESSOR IDER; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR   SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244893};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          1..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50944"
SQ   SEQUENCE   230 AA;  25165 MW;  9A8DE5855F51A173 CRC64;
     MTDLVDTTEM YLRTILDLEE EDIVPLRARI SERLGHSGPT VSQTVARMER DGLVVVSGDR
     HLELTSVGRL KATHVMRKHR LAERLLSDVI GLDWEFVHDE ACRWEHVMSE QVERKLIDML
     GNPTESPYGN PIPSLDDIGT SPSVAFLEGV TNLVGFVRGG GSGEVVIRRL GEPVQFDPEL
     LKQLKEAGIV PGSTAVVDDA GQYVSLRVDG HGDGIELPVE VAIHVFVAAG
//
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