ID A0A2V1HRP6_9MICO Unreviewed; 191 AA.
AC A0A2V1HRP6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=HIT family hydrolase {ECO:0000313|EMBL:PVZ94332.1};
GN ORFNames=DDQ50_11435 {ECO:0000313|EMBL:PVZ94332.1};
OS Amnibacterium flavum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Amnibacterium.
OX NCBI_TaxID=2173173 {ECO:0000313|EMBL:PVZ94332.1, ECO:0000313|Proteomes:UP000244893};
RN [1] {ECO:0000313|EMBL:PVZ94332.1, ECO:0000313|Proteomes:UP000244893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M8JJ-5 {ECO:0000313|EMBL:PVZ94332.1,
RC ECO:0000313|Proteomes:UP000244893};
RA Tuo L.;
RT "Amnibacterium sp. M8JJ-5, whole genome shotgun sequence.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVZ94332.1}.
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DR EMBL; QEOP01000002; PVZ94332.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V1HRP6; -.
DR OrthoDB; 9784774at2; -.
DR Proteomes; UP000244893; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:PVZ94332.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000244893}.
FT DOMAIN 51..160
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 145..149
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 147
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 77
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 149
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ SEQUENCE 191 AA; 20816 MW; 91792E78727FFBA3 CRC64;
MSDELPDEFA GVDARPTSSY AAAPDAFQRL WTPHRMAYIA AGGQPPSDEC PFCIAPTLSD
EDALIVHRGT HAFVLLNLFP YNSGHLLVCP YRHVALYDDA TEAEIDEIAR LTQTAMRVVR
ETAKTDGFNI GMNQGRVAGA GIADHLHQHV VPRWATDANF FPIIAETKAL PQLLGDVRRA
VADAWPVGDP A
//
