ID A0A2V1INP7_9BACT Unreviewed; 867 AA.
AC A0A2V1INP7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=C5O23_09325 {ECO:0000313|EMBL:PWB01556.1};
OS Duncaniella muris.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Muribaculaceae;
OC Duncaniella.
OX NCBI_TaxID=2094150 {ECO:0000313|EMBL:PWB01556.1, ECO:0000313|Proteomes:UP000244905};
RN [1] {ECO:0000313|Proteomes:UP000244905}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 103720 {ECO:0000313|Proteomes:UP000244905};
RA Clavel T., Strowig T.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWB01556.1}.
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DR EMBL; PUEC01000020; PWB01556.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V1INP7; -.
DR Proteomes; UP000244905; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000244905};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..152
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 163..483
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 308..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 664..691
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 867 AA; 99129 MW; 2DAB12BC56FB7B94 CRC64;
MNKQQLASKI WASANKMRSK IEANEYKDYI LGFIFYRYLS TEIENFYRTE GWSDEDMPSL
EEDIDPEYTE YVRKNRGYFI GYKNLFSTWL NKGNDFGVKD VSEALSAFNR LIYPTHKKVF
SGIFDTLETG LKNLGDSDTT RSSAISKLIQ LIKDIPMDGN QGYDVLGYIY EYLISNFAAS
AGKKAGEFYT PHEVSVLMAE IVAHHLRDRE KIEIYDPTSG SGSLLITIGR AVAKHNDSPD
NIKYYAQELK RNTYNLTRMN LVMRGIKPNN IITRNGDTLE HGSDWPMFED DDKETSYEYR
PMDAVVSNPP YSQEWDRPSD KDSDPRYKDY GLAPKKKADY AFLLHDLYHL KSDGIMAIVL
PHGVLFRPGD EAEIRRNLIE QNKIEAIIGL PADIFFGTPI ATIVMVLKAN RDNTDVLFID
ASKYASKDGK KKKLQASDIK RIFDAVTTRP ASIDKFARLV SLKEILENEY DLNIPKYVDS
SDAVEKWDLY SSLLGGVPRT EIELLKDYWE VMPALKSTLF PEGEYVECLS DNVGDTIRNH
DDIKKFQAAY NSAFGDYEQY LIAQLIYGMM TLNVAKEVDI LGEDLFNRLS SVPLLDRYAA
FQALSDCWEQ TATDIEIIQT EGREVLRKIE PNMVMVKNGE DEDEIQKGWK GRIMPFKLVQ
KTLLPEYLDR VNELQEQLAE TVGEVSALLE ETGEDDAEIL NEDGDAFDNK KVKVQLKLML
KEYKKRKYTD LPDFPEGSIE AHVVTLTKNA DEQKRLKAEV KDALRELEEK TIFTIESLTE
EQIRELLRLK WIMPVVDAVK AEHTNVITSL IDKVEALVVK YAVTLNDVEK SISESESKLS
DMVVSLRGND FDMKALESFK NLLNHGK
//
