ID   A0A2V1K9H7_9ACTO        Unreviewed;       338 AA.
AC   A0A2V1K9H7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:PWF27432.1};
GN   ORFNames=DD236_03365 {ECO:0000313|EMBL:PWF27432.1};
OS   Ancrocorticia populi.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Ancrocorticia.
OX   NCBI_TaxID=2175228 {ECO:0000313|EMBL:PWF27432.1, ECO:0000313|Proteomes:UP000245283};
RN   [1] {ECO:0000313|Proteomes:UP000245283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=sk1b4 {ECO:0000313|Proteomes:UP000245283};
RA   Li Y.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWF27432.1}.
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DR   EMBL; QETB01000001; PWF27432.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V1K9H7; -.
DR   OrthoDB; 9779574at2; -.
DR   Proteomes; UP000245283; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245283}.
FT   DOMAIN          8..334
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   338 AA;  37173 MW;  E62C8B07DBF3CC50 CRC64;
     MRDLNKLPKA HLHLHFTGSL SVSSLTSMAH EQDLRLPDTL TDNVALQVPA DQRGWFRFQR
     AYDAARAVVR SEESMRRIVR EAVADDAREG SRRLEIQIDP TSYAPFVGGI TPALEIVLDE
     ATNASREFGI EVGVIVAASR VRHPLEARTL ARLAAQYAGD GPGSVVGFGL SNDERRGITS
     EWAAAFNIAR RAGIPSVPHG GELLGPEHVR DVMAHLKPAR LGHGVRATED MDLARRIIDA
     GVAFEICPES NVSLGVYKEE DQVPVRQLME AGAQIALGAD DPLLFLSRLT DQYEILRRSG
     FSDRELAHLA RTSVEASFAS RESKARWRAE IDAWLAED
//