ID A0A2V2LME1_9RHOB Unreviewed; 1167 AA.
AC A0A2V2LME1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=addA {ECO:0000313|EMBL:PWR02903.1};
GN ORFNames=DKT77_10045 {ECO:0000313|EMBL:PWR02903.1};
OS Meridianimarinicoccus roseus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Meridianimarinicoccus.
OX NCBI_TaxID=2072018 {ECO:0000313|EMBL:PWR02903.1, ECO:0000313|Proteomes:UP000245680};
RN [1] {ECO:0000313|EMBL:PWR02903.1, ECO:0000313|Proteomes:UP000245680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TG-679 {ECO:0000313|EMBL:PWR02903.1,
RC ECO:0000313|Proteomes:UP000245680};
RA Ren Y.;
RT "Rhodobacteraceae gen. nov., sp. nov. isolated from sea water.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWR02903.1}.
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DR EMBL; QGKU01000032; PWR02903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V2LME1; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000245680; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000245680}.
FT DOMAIN 26..504
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 522..804
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 47..54
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1167 AA; 124444 MW; AD69F917DA60C5A0 CRC64;
MGPERHTRTR EGRPLTTTAS PARPATDEAT RRQIAAARPD LSTWLGANAG SGKTRVLTDR
VARLLLAGTP PQNILCLTYT KAAASEMQNR LFQRLGEWAM KPDADLRAAL GHLGVAGTLD
GAALDGARRL FAQAIETPGG LKIQTIHAFC AALLRQFPLE AGVSPNFTEL DDRSADALAA
EVLEDLADGP GAAALDRVAR HLSDDGRLGG LIASLLGHRA AFTPARDLPD LLAAHGLRTD
FDEAALVDTV FDGSERALLE TMIPVLQAKG GLDGKAAEKL APLLAGTLET GAALRVLEGV
LLTGKEAKAG AFVAKTDSFP TKPSRTKLGE TVTDALDALM ERVQDARPLR LGLASAQRSA
ALHAFAAVFL PAIAARKSAR GLLDFDDLIL RARDLLSRRA AADWVLFKLD GRIDHILVDE
AQDTSPEQWD VIRLLAQELT SGAGAREGVT RTIFVVGDKK QSIYSFQGAD PAAFDRLRGH
FDAALRDVGS SLQNAVLEHS FRSSAAILQA VDRTFALPDI GDAIGGTPSH IAFKDALPGR
VDLWGWVEPD PNKPEAPDWF DPVDKISPEA PDAVLARAIA AELRRLIDAG ETVPDGKGGR
EPLHEGHVLI LVRRRSVLFR EIIRACKAEG LDIAGADRLR LTRDMAVRDL MALLGFLALP
EDDLSLACAL RSPLLGWSED GLYRLAQPRP GTLWQALRAA APGSDTYEML MDLGDKADYL
RPFDLLERIL IRHKGREKLV ARLGPDCEEA IDALLGEALN YERANVPSLT GFLEWMRGDS
VDVKRQAEGA GRRLRVMTVH GAKGLEAPLV ILPDCGVLNA PKPPDIMLDP DSGLPLWTPN
APDTPEALAK AREASIARQE EERLRLLYVA MTRAESWLWV CASGKPDKHG TSWHARVEAG
LTGLGAAALD TPTGAGLRWQ HADWAALPLR GTAPAPLSAP ILPAWAGDAI PPRPAKAATT
ITPTALGGAK ALPGEAGLSE DDAKERGTRL HRLLEHLPAF PEASWTALAP GILGLADGPA
EEAMIADLLS EATAVLTAPA LRPLFAPGAL TEVGLVSPLP GLLPPPHDRL AGVVDRLIVT
GDHVLAIDYK SNARVPAGPE DVPEGILRQM GAYCAALEAI YPGARVETAL LWTRSAALMP
LPRTLVMAAL QRAVAEGPNL DARRSGP
//
