ID A0A2V2N908_9EURY Unreviewed; 1000 AA.
AC A0A2V2N908;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Chemotaxis protein CheA {ECO:0000256|ARBA:ARBA00021495};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=DK846_07500 {ECO:0000313|EMBL:PWR72787.1};
OS Methanospirillum lacunae.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX NCBI_TaxID=668570 {ECO:0000313|EMBL:PWR72787.1, ECO:0000313|Proteomes:UP000245657};
RN [1] {ECO:0000313|EMBL:PWR72787.1, ECO:0000313|Proteomes:UP000245657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ki8-1 {ECO:0000313|EMBL:PWR72787.1,
RC ECO:0000313|Proteomes:UP000245657};
RA Dueholm M.S., Nielsen P.H., Bakmann L.F., Otzen D.E.;
RT "Draft genome of Methanospirillum lacunae Ki8-1.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWR72787.1}.
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DR EMBL; QGMY01000006; PWR72787.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V2N908; -.
DR Proteomes; UP000245657; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR CDD; cd17909; CheC_ClassI; 1.
DR CDD; cd16916; HATPase_CheA-like; 1.
DR CDD; cd00088; HPT; 1.
DR Gene3D; 3.40.1550.10; CheC-like; 1.
DR Gene3D; 1.10.287.560; Histidine kinase CheA-like, homodimeric domain; 1.
DR Gene3D; 3.30.70.1110; Histidine kinase CheA-like, P2 response regulator-binding domain; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.120.160; HPT domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR004105; CheA-like_dim.
DR InterPro; IPR037006; CheA-like_homodim_sf.
DR InterPro; IPR037052; CheA-like_P2_sf.
DR InterPro; IPR010808; CheA_P2-bd.
DR InterPro; IPR007597; CheC.
DR InterPro; IPR028976; CheC-like_sf.
DR InterPro; IPR036061; CheW-like_dom_sf.
DR InterPro; IPR002545; CheW-lke_dom.
DR InterPro; IPR035891; CheY-binding_CheA.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR PANTHER; PTHR43395:SF10; CHEMOTAXIS PROTEIN CHEA; 1.
DR PANTHER; PTHR43395; SENSOR HISTIDINE KINASE CHEA; 1.
DR Pfam; PF04509; CheC; 2.
DR Pfam; PF01584; CheW; 1.
DR Pfam; PF02895; H-kinase_dim; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01627; Hpt; 1.
DR Pfam; PF07194; P2; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00260; CheW; 1.
DR SMART; SM01231; H-kinase_dim; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00073; HPT; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF103039; CheC-like; 1.
DR SUPFAM; SSF50341; CheW-like; 1.
DR SUPFAM; SSF55052; CheY-binding domain of CheA; 2.
DR SUPFAM; SSF47226; Histidine-containing phosphotransfer domain, HPT domain; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50851; CHEW; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50894; HPT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00110};
KW Reference proteome {ECO:0000313|Proteomes:UP000245657};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..103
FT /note="HPt"
FT /evidence="ECO:0000259|PROSITE:PS50894"
FT DOMAIN 350..638
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 640..769
FT /note="CheW-like"
FT /evidence="ECO:0000259|PROSITE:PS50851"
FT REGION 132..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 46
FT /note="Phosphohistidine"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00110"
SQ SEQUENCE 1000 AA; 109356 MW; C01F5F88C9B9D431 CRC64;
MSDLDAYRSL YVAESRENHE SIVSNLLILE QGTDSHAIDE IFRSAHSLKG MSASMGFMHM
EEICHALEDV FSQIRSGNLH VSQALMDDLL AGVDDIESMI DDIEAGGEGL LEHRDARVSA
LKAWLSGSSP STVEKKEPVI PDSGTEVEPA GDMYENPAYE SYDQAGNAEY KLHIELSSEV
DSINLRSMLI LQNLESIGSI SAISPSRTVV EDDPSFNGII DLTFVTNAGK AAVETILAIS
DIRSSSLSEE VSPQKKESVE PVPDFEHASR YAIHVELSPS VDSKNLRAML LLQNLESHGA
LTNISPRREV IEDSGTFSGI FDFELTSSDF SEEGIKSFLK GSDIKSSSVS LIQDVSDPIL
SGSGIEEHQN GTLAPSRISA GEKVEKKREV KNIRVDIDRL DHMMNLVEDL VINRGRLEQI
AQEYKIKELD ETLNMVGRSV ADLQVMMMDI RMIPLNHIFN RFPRTVRDIA TKEGKEVDFI
VEGGETELDR SVMDGLNDPL LHLIRNGLDH GIEPPDVRIR NGKNPKGTLK LSASRDKDNV
VIVIEDDGAG INQEKIKKKA LERGLATEEA LAAMSESEIN DLLFLPGFST ADKITDISGR
GVGLDVVRTT IASLQGTIKL ESVFGQGSRF ELVLPPTMAI VMVMMIRINN RRCAIPITNV
AEVASLAAFP IQNIGHGEGI LMRDEIIVLY RLDDMFGRSK SEEVIVVLQN QNRKGAVIAD
LIEGQQEVVI KPLSKFVGTC DGVSGVTIPG DGEVVPVLDV KAILREGSGQ KSAKKNSGKR
VKKVMKNNVI ADGEHLITDI QADELRELGN IGASHAATTL STILNTLISI HVPEIILVQL
QNLRYYLDDT EAAMVVFQIQ GQLVGNGYII IHIPKESIIR LTSIMLGQSA SDREIDDMDK
SALHEIGNIM TSSFLDACAT LLSIIMIPSP PSMVIDMPHA ALQSIIATQE IDENVDEVVL
FKTELQCAEY NISANIILLP SKGLLNELFA RMDSVISTSG
//
