ID   A0A2V2Z1S9_9BACL        Unreviewed;       268 AA.
AC   A0A2V2Z1S9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 9.
DE   SubName: Full=Phosphoribosyl 1,2-cyclic phosphodiesterase {ECO:0000313|EMBL:PWW08802.1};
GN   ORFNames=DFQ01_101528 {ECO:0000313|EMBL:PWW08802.1};
OS   Paenibacillus cellulosilyticus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=375489 {ECO:0000313|EMBL:PWW08802.1, ECO:0000313|Proteomes:UP000246635};
RN   [1] {ECO:0000313|EMBL:PWW08802.1, ECO:0000313|Proteomes:UP000246635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 5696 {ECO:0000313|EMBL:PWW08802.1,
RC   ECO:0000313|Proteomes:UP000246635};
RA   Whitman W.;
RT   "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT   soil and plant-associated and newly described type strains.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Counteracts the endogenous Pycsar antiviral defense system.
CC       Phosphodiesterase that enables metal-dependent hydrolysis of host
CC       cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
CC       {ECO:0000256|ARBA:ARBA00034301}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic CMP + H2O = CMP + H(+); Xref=Rhea:RHEA:72675,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58003,
CC         ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00034221};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72676;
CC         Evidence={ECO:0000256|ARBA:ARBA00034221};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic UMP + H2O = H(+) + UMP; Xref=Rhea:RHEA:70575,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57865,
CC         ChEBI:CHEBI:184387; Evidence={ECO:0000256|ARBA:ARBA00034227};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70576;
CC         Evidence={ECO:0000256|ARBA:ARBA00034227};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWW08802.1}.
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DR   EMBL; QGTQ01000001; PWW08802.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V2Z1S9; -.
DR   OrthoDB; 9781189at2; -.
DR   Proteomes; UP000246635; Unassembled WGS sequence.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR47619; METALLO-HYDROLASE YYCJ-RELATED; 1.
DR   PANTHER; PTHR47619:SF1; METALLO-HYDROLASE YYCJ-RELATED; 1.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000246635}.
FT   DOMAIN          13..218
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   268 AA;  29901 MW;  93721996FB0A26ED CRC64;
     MGFRFTVLSS GSTGNATVVQ NDEHTVLVDA GLSAKRIDQL LADRGVSGHS IDALFVTHEH
     SDHIKGLGAV ARKYNLPIFA NAATWEAMEK HVGNIAPEKR TIMESGETVS FGNMRVTSYP
     ISHDAAEPVG YCMTEDGYKL SLATDLGYVS DKVKQAIIDS DVLVLESNHD TEMLRMGRYP
     WNIKRRILSD VGHLSNVAAG EALCELMTDR TKRVYLAHLS LDHNVMDLAK LTINGIFENN
     GIFFKRDEDP LRDTYYDRAT PWDEVKRR
//