ID A0A2V3VNP1_9PROT Unreviewed; 607 AA.
AC A0A2V3VNP1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Kef-type potassium/proton antiporter (CPA2 family) {ECO:0000313|EMBL:PXW83442.1};
GN ORFNames=C8R34_1284 {ECO:0000313|EMBL:PXW83442.1};
OS Nitrosomonas sp. Nm84.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=200124 {ECO:0000313|EMBL:PXW83442.1, ECO:0000313|Proteomes:UP000248024};
RN [1] {ECO:0000313|EMBL:PXW83442.1, ECO:0000313|Proteomes:UP000248024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm84 {ECO:0000313|EMBL:PXW83442.1,
RC ECO:0000313|Proteomes:UP000248024};
RA Wagner M.;
RT "Active sludge and wastewater microbial communities from Klosterneuburg,
RT Austria.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PXW83442.1}.
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DR EMBL; QJJP01000028; PXW83442.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V3VNP1; -.
DR Proteomes; UP000248024; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004771; K/H_exchanger.
DR InterPro; IPR006036; K_uptake_TrkA.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR NCBIfam; TIGR00932; 2a37; 1.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR PRINTS; PR00335; KUPTAKETRKA.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000248024};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 405..526
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT REGION 579..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 65077 MW; AB6B04C89775CAC9 CRC64;
MSEVTSPVDL LKVVTLLGAA VVMVPIFRRL GLGSVLGYLV AGLIIGPFGL QLFSDSHTIL
HVAELGVVMF LFVIGLEMRP SHLWSLRRDI FGLGSLQIIF CTIALTGIGI AFGFSVAVSF
ISAMGFVLTS TAIVMQLLEE RGDIALPRGQ KIVAILLFED LLIIPLLAIV ALMSPNVVES
AQGSSLLAVA IGVGSLAGVI VCGVWLLNPL FRVLAMAKAR EVMTAAALFV VLGSALLMQI
SGLSMAMGAF LAGVLLAESS FRHQIEADIE PFRGILLGLF FIGVGMSLNL DVVIESWVLI
LTATLAMMAI KALCIYIVAR LSGTSNANAI DRMFLMAQGG EFAFVLFTAA AAASVIDATV
NANMTAVVVL SMGLTPLFVA IYKKLAPVIA ESKEDVEDAN GLSGSVLLIG FGRFGQVISQ
LLLARNVDVT IIDSNPNMIR NASKFGFKIY YGDGSRLDVL RASGAHNARA ILVCVDQKSI
SNRIVELVKS EFPLAKLLVR SFDRTHSREL VQRGVDFQIR ETFESAFLFG QATLHELGVT
EEEIAIIAND IRSRDTERFQ LEIAGGEYAG RDLVLSNTQE QTPLLPPKRE ATALTQDTAT
EVNTPES
//
