ID   A0A2V4A1I1_9BACT        Unreviewed;       817 AA.
AC   A0A2V4A1I1;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=CBS domain-containing protein {ECO:0000259|PROSITE:PS51371};
GN   ORFNames=DF185_00420 {ECO:0000313|EMBL:PXY02592.1};
OS   Marinifilum breve.
OC   Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinifilaceae.
OX   NCBI_TaxID=2184082 {ECO:0000313|EMBL:PXY02592.1, ECO:0000313|Proteomes:UP000248079};
RN   [1] {ECO:0000313|EMBL:PXY02592.1, ECO:0000313|Proteomes:UP000248079}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC075 {ECO:0000313|EMBL:PXY02592.1,
RC   ECO:0000313|Proteomes:UP000248079};
RA   Fu T.;
RT   "Marinifilum breve JC075T sp. nov., a marine bacterium isolated from Yongle
RT   Blue Hole in the South China Sea.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PXY02592.1}.
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DR   EMBL; QFLI01000001; PXY02592.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V4A1I1; -.
DR   OrthoDB; 9810264at2; -.
DR   Proteomes; UP000248079; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008773; F:[protein-PII] uridylyltransferase activity; IEA:InterPro.
DR   CDD; cd05401; NT_GlnE_GlnD_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR018821; DUF294_put_nucleoTrafse_sb-bd.
DR   InterPro; IPR005105; GlnD_Uridyltrans_N.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR033480; sCache_2.
DR   PANTHER; PTHR43080:SF31; CBS DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43080; CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03445; DUF294; 1.
DR   Pfam; PF10335; DUF294_C; 1.
DR   Pfam; PF17200; sCache_2; 1.
DR   SMART; SM01049; Cache_2; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS51371; CBS; 2.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          370..429
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          434..492
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   817 AA;  93552 MW;  C0BF3C940E94F5BB CRC64;
     MKKANNKFIY SIVIPTIIAI SMFVITFYLI LIPLFERSMM DRKKEMISEL TNAAWSVLSE
     YQEAYHNGEI SLAEAQEKAS EHVGKMRYGS EQKDYFWIIT NSPKMIMHPY RPELNNTDLS
     NFSDNHENKL FVDAANLVKK EGEGFIQYYW QWKDDASKIS PKLSYVKGFS DWNWVIGTGI
     YLDDVEMEIS QLKKTLLKIS FTIILFIGFI LLYVLRQSRI IEEKRLKAEK QLLSSIQKYK
     SLVNASTEGT LMLVDEKVVF ANNKFTKLFD NESIVGSSFS SLFKMSWSDL VSKIENPQKT
     STFETELVNA QAGRETVVIS VTQITLSGEV GYIIVAKNVT EKKRLRLDAN KISEDIQLSL
     QLMNQPIDNL IQKNVCCQLN TSIKEAAKLM TDQNCKLVCI KERDQIIGII TDTDLRTRVL
     ANDKNTDDTV ATIMTAPVIS IKHDALLYEA ILRFKQSKVS HLLIENEYGN IIGNISSKQC
     LEMQQNSLTH LINQINDCNN VESIKRIHNK VPILIQAVFT SSENINSVSR IITSIADTIS
     SRIIELAIQE VGPAPCKFAF ITMGSEGRSE QTLKADQDNA IIFANDSDDN KSYFLRLSEI
     INENLHAIGY SRCKGDLMAG NPEWCNSIDV WKNYFSNWID NPDMPNVLDS SIFLDLRSIY
     GDNSLVDDLF EHVYSELDHH HDFYNQLAKT VIGVKPSFNK KAVNIKKFLQ PIIGYLRIHA
     LHHSIRETNS LLRLNQLMAL GVISEKNAEE IEAMYNFLMH LRMKWQVNLI LDNDWPENEV
     LLKNLTELDK ATFKRIEKEI ASLQDELKTA FKISEYQ
//