ID   A0A2V4A1N3_9BACT        Unreviewed;       450 AA.
AC   A0A2V4A1N3;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN   ORFNames=DF185_00675 {ECO:0000313|EMBL:PXY02642.1};
OS   Marinifilum breve.
OC   Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinifilaceae.
OX   NCBI_TaxID=2184082 {ECO:0000313|EMBL:PXY02642.1, ECO:0000313|Proteomes:UP000248079};
RN   [1] {ECO:0000313|EMBL:PXY02642.1, ECO:0000313|Proteomes:UP000248079}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC075 {ECO:0000313|EMBL:PXY02642.1,
RC   ECO:0000313|Proteomes:UP000248079};
RA   Fu T.;
RT   "Marinifilum breve JC075T sp. nov., a marine bacterium isolated from Yongle
RT   Blue Hole in the South China Sea.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PXY02642.1}.
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DR   EMBL; QFLI01000001; PXY02642.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V4A1N3; -.
DR   OrthoDB; 9811110at2; -.
DR   Proteomes; UP000248079; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13140; MATE_like_1; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR   PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   4: Predicted;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        392..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        419..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   450 AA;  49424 MW;  F51C56534FB0312D CRC64;
     MIRFLARFFK REQQYSAVGK DLLKLAIPII GSYLLHTAYN LTDMIWVGSL GSNAVAAVGS
     AGFFLHLGWA MASIVTVGAN IKISHSVGAK DEEGAGRFAT SALWGIGLIA TVFSAIFWGF
     PEKFINFFQM QDPEVNEMAT SYLVISTFGV ILSYANLLFI SMFNAHSETK VSFKSSLIGT
     AANIVLDPIL IFGLSLGVDG AAYATIIGRL LSLLYFLYIY KKTANINFRG ILPCLDKFKT
     IFAVGTPAAV QRISFSIIYI FLARIIADWG PNAIAVQKIG VQIESITFMI VGGFMQAVTI
     MVGQNYGAKN LTEVPNIYRA GWRMSFIVGS VTTVLFLLIP KTLFSIFVPE EESILMGKEY
     LMILAVSQLF MCLEMINAGV FNGLGKTKIS AVVSVIFTSL RLPGAYFLGF YTFLSLNGVW
     WSITGSSILK GIVMYMLLRA YMKKDTFGKI
//