ID A0A2V4MTA8_9ACTN Unreviewed; 1657 AA.
AC A0A2V4MTA8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PYC66985.1};
DE Flags: Fragment;
GN ORFNames=C7C46_30815 {ECO:0000313|EMBL:PYC66985.1};
OS Streptomyces tateyamensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=565073 {ECO:0000313|EMBL:PYC66985.1, ECO:0000313|Proteomes:UP000248039};
RN [1] {ECO:0000313|EMBL:PYC66985.1, ECO:0000313|Proteomes:UP000248039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21389 {ECO:0000313|EMBL:PYC66985.1,
RC ECO:0000313|Proteomes:UP000248039};
RA Schwalen C.J., Hudson G.A., Mitchell D.A.;
RT "Bioinformatic expansion and discovery of thiopeptide antibiotics.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PYC66985.1}.
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DR EMBL; PYBW01000158; PYC66985.1; -; Genomic_DNA.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000248039; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248039};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 875..950
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 969..1381
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PYC66985.1"
FT NON_TER 1657
FT /evidence="ECO:0000313|EMBL:PYC66985.1"
SQ SEQUENCE 1657 AA; 171762 MW; 47633A75797A580A CRC64;
HVRGTVRFAD ALTTLVNDGV TRFVEVGPDA ALTPMRLDDP SLLFVATARR DRDEVRELVA
ALGTVHAHGV RVNWPGFFAG RGAQRVDLPT YAFQRRRFWL EQQPATGDVT SVGLDPADHP
LLGAAIALAD TGGYLFTSRL SVQSHPWLAD HDTLGSVLLP GTAFVELALR AGQQAGCDLL
EELTLQSPLL LPEQGGVQVQ VLVGAADESG SHPVSILSRR EGLDLPWTLN AAGSLAAGAP
VPDFELADWP PVGAEPIEVE GAYEKLAGGG CYAYGPAFQG LQAAWRRGAE VFAEVVLPNA
AEADAGKYGL HPAALDACLH VALVDDQAPG AGEIVLPFAW EGVSLHAAGA AALRVRITPG
SGDSVALAVA DQSGRPVLSA ASMISRPVSL EQLSAPQAEP VHQLAWQPLA DRPAAPAAVA
VAVLGADHGD HADHADYANY ADLAALRAAV AAGTPAPELV LCNVPSSEGE LLTAVRARLA
EVLELAQEWS TAPEFASAKL AVVTTGAVHT GTGDQPLDLA AAPVWGLLRA AQAEHPDRFV
LLDTDGHPGS TGLLAAAAAT GEPELALRAD VLYCTRLVRA TAAAQPLALD QAGTVLITGG
TGGLGARVAR QLAERHGVRH LLLTSRRGSA TPGAAELVAE LAELGAEATV AACDVADRSA
LAELLAAIPA AHPLTGVVHS AGVLDDGLLD ALTPERFDAV LRPKADAAWH LHELTKEQPL
SLFVLFSSAA GSLGAAGQAN YAAANVFLDT LAAHRRTIGL AGQAQAWGLW AEGGMGDQLD
EADVRRLTRQ GFPPLSVAEG LALFDAALTT PVSGAVLLRL DLAALRALAV AGTVQPVLTE
LVKVPARQGG STTAGGSAGA LRARLAGLGE AEAERELLAL VQDQVAAVLG HASGAEVEPD
RAFQELGFDS LAALELRNAL NSATGLKLSA TLTFDYPTSA AVAGHLGEQL AGAVAAVAAT
RPVAARSGDE PIAIVAMACR YPGEVSTPEQ LWQLVADGRE AITGLPANRG WDLDGGYDPE
PGTPGKYYTR GGGYLLDAGR FDAGFFGISP NEARSMDPQQ RLLLETSWEA FERAGIDPGT
LKGSATGVFA GVMYHDYALN NATGSIASGR LSYVFGLEGP AVTVDTACSS SLVALHLAVQ
ALRSGECSLA LAGGVTVMAT DETLVDFSQQ RGLSPDGRCR SFATSADGTG FSEGAGMLLV
ERLSDARRNG HPVLAIVRGS AINQDGASNG LTAPNGPAQQ RVIRQALANA QLTVDQIDAV
EAHGTGTVLG DPIEAQALLA TYGQERGAAG PLLLGSIKSN MGHTQAAAGV AGIIKMVQAM
EHGVLPRTLH VDEPSSKVDW SAGAVELLTE AREWPAVERP RRVGISSFGL SGTNAHVILE
QPPAAVVEET VAGANELPVV PWLLSAKTPE ALREQAARLR AWVADRPQLR PVDVAYSLAT
GRAPFEHRAA VLGANREALL DALSRPVSPV VRGNGRTAFL FSGQGSQRVG MGRQLAAAFP
VFAAAWDELA GHLDLGSDEE LNQTQYAQPA IFAFEVALFR LLESWGVRPD YLAGHSIGEI
AAAHVAGVFS LEDAAKLVTA RGRLMQALPA GGAMLAVEAT EAEVTGLGVD VAAVNGPRAV
VLSGPEADID RVAEHFADRR TKRLTVSHAF HPSLMDP
//
