ID   A0A2V4MWV5_9ACTN        Unreviewed;       958 AA.
AC   A0A2V4MWV5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=SARP family transcriptional regulator {ECO:0000313|EMBL:PYC66072.1};
GN   ORFNames=C7C46_31775 {ECO:0000313|EMBL:PYC66072.1};
OS   Streptomyces tateyamensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=565073 {ECO:0000313|EMBL:PYC66072.1, ECO:0000313|Proteomes:UP000248039};
RN   [1] {ECO:0000313|EMBL:PYC66072.1, ECO:0000313|Proteomes:UP000248039}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 21389 {ECO:0000313|EMBL:PYC66072.1,
RC   ECO:0000313|Proteomes:UP000248039};
RA   Schwalen C.J., Hudson G.A., Mitchell D.A.;
RT   "Bioinformatic expansion and discovery of thiopeptide antibiotics.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000256|ARBA:ARBA00005820}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PYC66072.1}.
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DR   EMBL; PYBW01000186; PYC66072.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V4MWV5; -.
DR   OrthoDB; 581105at2; -.
DR   Proteomes; UP000248039; Unassembled WGS sequence.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR   PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00028; TPR; 3.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248039};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          17..90
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000259|SMART:SM00862"
FT   DOMAIN          97..241
FT                   /note="Bacterial transcriptional activator"
FT                   /evidence="ECO:0000259|SMART:SM01043"
FT   REGION          245..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   958 AA;  103420 MW;  6A7A41E054A6DA70 CRC64;
     MQYRVLGSLE VRLGERQVEV ERPRRRALLA FLLLNANQYV TTERLVDALW GEAPPASARG
     QLHTALSELR KLLGTGETGP LGFRNGAYLL SVDEGCLDAT AFRHSVGEAR RLRESGAAVE
     AARVIRAGLG LWRGGALTGI DAPFAEPVRT LLEEERSTAY ELLADIELDL GRHQQLVPEL
     TELIERYPAR EGLAERLMLA LHRGGRQTDA LAVARRVRKV LAEDFGLDPG RSLVELEGAI
     LRDEPGLRPD AAPGAATAGT AAPAVPAGAG ASWSERWGDA PRPAQLPSSA RGFVGRTAET
     ARLDDVLADA AAGPRIAVVT GPAGAGKTAL AVRWAHTRSA DFPDGQLFVD LRGYAEGDCE
     DPAHVLERFL VALGVPGPQV PSGVAARADL YRSSLSNRRV LVILDNARDI GQVRPLLPGA
     PGCLTLVTSR DALGSLVVEA GAVPVRLARM TPEQSVEVLS GILGTERVAA EPEQATELAR
     LCGELPLALR ITAARLVEDP EAPLAELVAE LSGEPTRLDG LELPGDQSSA VARALDHSYR
     QLQPEQARFF RLLGIQPGQL GAAAITALTS TGPVLPTAAT AASRRLLREL EAVHLVERPR
     SDRYALHDLV RLYAQHRTGM DAAEREAATR RLFDWYICVS TEAERQLDPL RSSIEPQVDH
     QLDTPDLFPD TESAVAWFDL EAENLLATTR LAAAVGDHRA VWQLADHQFG HFMRSHRLDA
     FVESFELAEV AAQRAGNQEA AAMMANGLGV AHSFRRDVPS AKAAYERALA LYQELGDRMR
     ALTARANLGN LLFEVGLLAE ARAYQEVAVA GARELEHPRI LGIFLSNLAL TIGDLGEYQA
     SEALQEEALL VLDTHCPQER QYVFRGNLAR VRAALGKYES AAAECRLALV EARGHGDTLH
     TARLLCQLGD CQKLSGQSDQ ARVSWQEALD AFTECGSSQA EVAVQRLADD DVPKGAYR
//