ID A0A2V4NXL6_9ACTN Unreviewed; 770 AA.
AC A0A2V4NXL6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Helicase {ECO:0000313|EMBL:PYC66492.1};
GN ORFNames=C7C46_31405 {ECO:0000313|EMBL:PYC66492.1};
OS Streptomyces tateyamensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=565073 {ECO:0000313|EMBL:PYC66492.1, ECO:0000313|Proteomes:UP000248039};
RN [1] {ECO:0000313|EMBL:PYC66492.1, ECO:0000313|Proteomes:UP000248039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21389 {ECO:0000313|EMBL:PYC66492.1,
RC ECO:0000313|Proteomes:UP000248039};
RA Schwalen C.J., Hudson G.A., Mitchell D.A.;
RT "Bioinformatic expansion and discovery of thiopeptide antibiotics.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PYC66492.1}.
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DR EMBL; PYBW01000174; PYC66492.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V4NXL6; -.
DR OrthoDB; 9787585at2; -.
DR Proteomes; UP000248039; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000248039}.
FT DOMAIN 222..618
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 243..250
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 770 AA; 83221 MW; 1A7BB9B1FDAB761B CRC64;
MAAQGSQHAA APATAAREGL REREIAGEQR HLDTVYRRLE EKLAEAEYVL EDAAKRVQVG
TPGALAERDA QVFRAGAHLH RLNNEFEDFL FGRIDLQQAD APEEHGIPSF TPLDAADPNV
AQSLHIGRLG VLDAEFGPLV IDWRAPAAAP FYRATPLEPG RVLRRRVIRS KGRKVIGVED
DLLRPDLAPV LDGEELAVIG DGALMASLGR ARSHTMRDIV SSIQKEQDEV IRAPAAGATL
VTGGPGTGKT AVALHRAAFL LYQDRRRYAG GILVVSPTPL LVSYTEGVLP SLGEEGQVAI
RAIGSLVDGV EAGRYDTPET ARIKGSARMV QLLRRAARAA LELHAPTELK VVARGEVLRL
DAARLHAVRG QVVGGGGTPL NLLRPRARRL LLDALWAEAV RDLPRPGDHY AREQRQEEKE
AFDEYVSDEA PFLDFLQAWW PALTPRQVLG TLKSSRHTNR IARRAVTGEE ARLLAASWRH
LGERGEGAVS AHDVALLDEL QQLLGEPARP RTREVDAVDL LTGLDEVTTF ADRTARVRER
GPVERTEYAH VIVDEAQDLT PMQWRMIGRR SRTATWTIVG DPAQSSWPFP QEAQAAMDEV
LGGKPRRRHT LTVNYRNPAE IAEVAAKVLA LAAPGTPSPT AVRSTGTLPR FAAVTATGPG
AFAAAARAEL VRLLGEVEGT VAVVVPMDRR AEAAGWAEGL GERVVALGSL EAKGLEYDAT
VVADPTGIAG ESEGGLRVLY VALTRATQRL TVLSGPDDLP DSRGVPALLR
//
