ID A0A2V4WUC5_9FLAO Unreviewed; 777 AA.
AC A0A2V4WUC5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DFQ11_10691 {ECO:0000313|EMBL:PYE80291.1};
OS Winogradskyella epiphytica.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Winogradskyella.
OX NCBI_TaxID=262005 {ECO:0000313|EMBL:PYE80291.1, ECO:0000313|Proteomes:UP000248054};
RN [1] {ECO:0000313|EMBL:PYE80291.1, ECO:0000313|Proteomes:UP000248054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7945 {ECO:0000313|EMBL:PYE80291.1,
RC ECO:0000313|Proteomes:UP000248054};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PYE80291.1}.
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DR EMBL; QJTD01000006; PYE80291.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V4WUC5; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000248054; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000248054}.
FT DOMAIN 6..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 684..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 777 AA; 88516 MW; D5E4C9B0F3E924BD CRC64;
MEKYLSQLNE AQLAPTIQVN GPMIIIAGAG SGKTRVLTYR IAYLMSKGVD SFNILALTFT
NKAAKEMKER IAQIVGDGEA KNLWMGTFHS VFAKILRFEG HHLGFPSNFT IYDTQDSQKL
MGSIIKEMGL DKDIYKTKQV YSRISSYKNS LITVKAYFKN PELMEADAMA RRPRMGEIYK
EYVDRCFKAG AMDFDDLLLR TNELLTRFPN VLAQYQDKFR YILVDEYQDT NHSQYLIVRA
LADRFQNICV VGDDAQSIYA FRGANINNIL NFQKDYDNVK MYRLEQNYRS TKNIVGAANS
VIEHNKTKLD KVVWTANDVG EKVIVHRALT DGDEGRYVAS TIWETKMNQQ LNNNDFAVLY
RTNAQSRAIE DALRKRDIPY RIYGGLSFYQ RKEIKDVTAY LRLILNSADE EALKRVINYP
GRGIGQTTID RLIVAANQTG KTIYDVIKDI DSVPININNG TKNKLRDFVT LIESYKVMNQ
TANAFDLAEH VTKTSGLIRE LNKDGTPEGV TRMDNVQELL NGIKDFVEGQ MELADAGDSL
AEFLEDVALA TDMDADKGDP DHVALMTIHL AKGLEFGHVF IVGMEEDLFP SAMSMNTRSE
LEEERRLFYV ALTRAEKQAY LTYTLSRYRW GKLIDAEPSR FIEEIDEQFV DITTPLKERF
NPMLDPSIFD DVEPNRVRFA KPKTAKIKKK EPKKQPEKFQ ISTPKKLKPV SKTEKAPSSF
DTKLVVGDTV NHQRFGRGEV MKIEGSGGDI KAEIKFQNGA TKKLLLRFAK LEILRTK
//
