ID   A0A2V5JG66_9EURO        Unreviewed;      1027 AA.
AC   A0A2V5JG66;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=NRPS-like enzyme {ECO:0000313|EMBL:PYI35296.1};
GN   ORFNames=BP00DRAFT_480510 {ECO:0000313|EMBL:PYI35296.1};
OS   Aspergillus indologenus CBS 114.80.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1450541 {ECO:0000313|EMBL:PYI35296.1, ECO:0000313|Proteomes:UP000248817};
RN   [1] {ECO:0000313|EMBL:PYI35296.1, ECO:0000313|Proteomes:UP000248817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 114.80 {ECO:0000313|EMBL:PYI35296.1,
RC   ECO:0000313|Proteomes:UP000248817};
RG   DOE Joint Genome Institute;
RA   Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA   Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA   Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA   Mortensen U.H., Andersen M.R., Baker S.E.;
RT   "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT   speciation.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NRP synthetase family.
CC       {ECO:0000256|ARBA:ARBA00029454}.
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DR   EMBL; KZ825470; PYI35296.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2V5JG66; -.
DR   Proteomes; UP000248817; Unassembled WGS sequence.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd05235; SDR_e1; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR010080; Thioester_reductase-like_dom.
DR   NCBIfam; TIGR01746; Thioester-redct; 1.
DR   PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   3: Inferred from homology;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450}.
FT   DOMAIN          530..605
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1027 AA;  113703 MW;  1A281A18A843CCF4 CRC64;
     MGSLFQSTID GIISANTAKA PQATAVEDGD RKLSYQELER KVVNLTSMLA EHDLKHEEPV
     CILADLGVEV VVAQLAVIRL GLTCIPLITC TPRLRLMSIL KDVEARYVLS DSKDIPLGSE
     FTVLPITVDG EEWQGHDADR ASCADGVDGN QSSFLECQNP NYRTHILYTS GSTGKPKPVQ
     VMERSILHLA SKSPLGILDP TDKVAVINNP GFDISLFEIF PGLIAGATLV IVPRMVVTDP
     FTFREFIVEK GLSVIYLTST LFGIIAHACP TTFHNVKHLL IGGSAANVAA VKAVVNSSLP
     PKYLWNTYGP TEITTHAVMH LVTPSEFKYD NIGLGKPFGN GRLRLVDEDL STITTPGVVG
     EVLLTGPGLT RGYVGLPKEN EYRFLQLEDG LRYYRSGDRA KWRKGEADVL EFAGRTDFQV
     KQGGFRVELE EIQHMLLSSG QLVGAVVVQV PGSSVTVGAF IVAFVIPAIA DTLRVGALEE
     YLGERLPGYM IPSDIVFLQE FPLNDHGKID RKALIHKYLM EREHKKSEFE DSRDTATIVR
     GLWSSLLNKP SFNQDDDFFR LGGTSLQAAA LIAKLREHTG RTISMRGLVE NSQLHELVAY
     LGEFVEGGNA PDDADCWIAD ARLTDDLKIN PAWSAQDWES VIDWTAPGEG RLFLTGVTGF
     VGAHFLFRFL NMPEVQEVVC LARAKSGQTP RQRVEHTLKR YEFHERVAHQ LAKLTVLEGD
     ITQKDLGLSA SEYTQLADRT SAIFHIAAKV NYCEPYSAHF EPNVLGTKNL LELAAQGRRK
     AFHYMSSLDA WGATGLIYGT RVLLEDEPLL PHIGSLPFDI GYASSQWVAE QMVRGARDRG
     LPAVIYRPGF VIGDTKHGAG NPDDFVSRLF MGSIRLGAFP HLPSQRMEFV TVDYVCDATL
     HIASKKNSFG RSYCLVPPSP AISVDMEKTY EILVEAGYAL RLLPYWDWVR ELQEIEDQDN
     PLNPLLPMLQ EPVISGLSRF QTSRQTPWYD CSNTLAALKD APEIKYAPLS VDLLTTILRF
     WRRIGAF
//