ID A0A2V5JJL6_9MICC Unreviewed; 971 AA.
AC A0A2V5JJL6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cell division protein FtsK {ECO:0000313|EMBL:PYI37446.1};
GN ORFNames=CVS30_15605 {ECO:0000313|EMBL:PYI37446.1};
OS Arthrobacter psychrolactophilus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=92442 {ECO:0000313|EMBL:PYI37446.1, ECO:0000313|Proteomes:UP000247980};
RN [1] {ECO:0000313|EMBL:PYI37446.1, ECO:0000313|Proteomes:UP000247980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:PYI37446.1,
RC ECO:0000313|Proteomes:UP000247980};
RA Liu Q., Xin Y.-H.;
RT "Genetic diversity of glacier-inhabiting Cryobacterium bacteria in China
RT and description of Cryobacterium mengkeensis sp. nov. and Arthrobacter
RT glacialis sp. nov.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PYI37446.1}.
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DR EMBL; QJVC01000022; PYI37446.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V5JJL6; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000247980; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000313|EMBL:PYI37446.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000247980};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 87..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 548..748
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 565..572
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 971 AA; 102504 MW; 01B1F1BB147C3810 CRC64;
MATRSTSARS STGQKGSTSS RAPKTTKTPV SRSKPSASGQ EVHLVWPVRV AVSFWQGFGH
LVGAAIRRMG TDKGAMPAEE RRDGAGLLFF LLALVTATFE WWGLTGPLAD SVRGIFQGSF
GWFSVLLPPM FLIFSVLVFR QPSNMSTNNR VALGFSILTL AGCALAHVAA GNPNISDGFA
GISAAGGMVG VLSGGLVANL GSVTSLIVFS LVAFASVLVL SNTPVRHIPA RLRGIYEKLM
GTEPGYSDGA LPNGHDQSYL YEHAAESKKP RSLRARQKAA REAEDEFEDV VGTEAFATPI
IELDDDGAPI PASKSPSLRP GVRRPTRDQL AADKIKARQG LPTSSDVFDV AADGEPVTEA
IGVIASPTGR ATAGAGVYDF DAAATQAMPA PPLAPPTPIP ARSEQLLLSG DVTYTLPDSE
FLPAGPPGKD ATEANDTVVA ALTDTMQQFN VDAKVTGFSR GPTVTRYEIE LAPGTKVERV
TALSKNISYA VASSDVRILS PIPGKSAIGI EIPNADKEIV VLGDVLRSAN ARRTEHPMVM
GVGKDVEGGF VVANLAKMPH LLVAGATGAG KSSFVNSMIV SILMRATPDE VRMVMVDPKR
VELTAYEGVP HLITPIITNP KKAAEALQWV VREMDQRYDD LANYGFKHID EFNKAVKAGN
VHPPVDSKRV VRPYPYLLVI VDELADLMMV APRDVEDSIV RITQLARAAG IHLVLATQRP
SVDVVTGLIK ANVPSRMAFA TSSVTDSRVV LDQPGAEKLL GQGDALFLPM GKSKPVRVQG
AWVTEAEIKA VVDHVKGQLK ATYREDVAAE APKKVIEDDI GDDMDVLLQA TELVVTTQFG
STSMLQRKLR VGFAKAGRLM DLLESRGVVG PSEGSKARDV LVKPDDLAET LAAIRGDGGA
GGGSAVGPSA GLPAAPTVDP KIAALSENAN ANHGWGGDLV ADDLASRPQA VDYNDGADDE
DGEDAWSLTG R
//
