ID A0A2W0H8T5_9BACI Unreviewed; 374 AA.
AC A0A2W0H8T5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=nicotinate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00013236};
DE EC=6.3.4.21 {ECO:0000256|ARBA:ARBA00013236};
GN ORFNames=CR205_00765 {ECO:0000313|EMBL:PYZ97166.1};
OS Alteribacter lacisalsi.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Alteribacter.
OX NCBI_TaxID=2045244 {ECO:0000313|EMBL:PYZ97166.1, ECO:0000313|Proteomes:UP000248066};
RN [1] {ECO:0000313|EMBL:PYZ97166.1, ECO:0000313|Proteomes:UP000248066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YSP-3 {ECO:0000313|EMBL:PYZ97166.1,
RC ECO:0000313|Proteomes:UP000248066};
RA Wang H.;
RT "Bacillus sp. nov., a halophilic bacterium isolated from a Yangshapao
RT Lake.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O +
CC nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide +
CC phosphate; Xref=Rhea:RHEA:36163, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:32544, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017,
CC ChEBI:CHEBI:456216; EC=6.3.4.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001240};
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-
CC ribonucleotide from nicotinate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004952}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PYZ97166.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PDOF01000001; PYZ97166.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W0H8T5; -.
DR OrthoDB; 9770610at2; -.
DR UniPathway; UPA00253; UER00457.
DR Proteomes; UP000248066; Unassembled WGS sequence.
DR GO; GO:0004516; F:nicotinate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016763; F:pentosyltransferase activity; IEA:InterPro.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01571; NAPRTase_B; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1170.20; Quinolinate phosphoribosyl transferase, N-terminal domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR035809; NAPRTase_arc-type.
DR InterPro; IPR007229; Nic_PRibTrfase-Fam.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR InterPro; IPR037128; Quinolinate_PRibosylTase_N_sf.
DR InterPro; IPR022412; Quinolinate_PRibosylTrfase_N.
DR PANTHER; PTHR43202:SF1; NICOTINATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43202; NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE; 1.
DR Pfam; PF02749; QRPTase_N; 1.
DR PIRSF; PIRSF000484; NAPRT; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
DR SUPFAM; SSF54675; Nicotinate/Quinolinate PRTase N-terminal domain-like; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:PYZ97166.1};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:PYZ97166.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000248066};
KW Transferase {ECO:0000313|EMBL:PYZ97166.1}.
FT DOMAIN 50..124
FT /note="Quinolinate phosphoribosyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02749"
SQ SEQUENCE 374 AA; 42199 MW; EC8B8C705401C15B CRC64;
MSEKEIYQKL QGRIKRLTNK TFKFDERIGD GWFSAVYFLK TREIAEKYKP DNEILMQFFQ
KKNAVLCGTD EVLALLKTFA KNPGELEVHS LEDGDRIEPF ETVMTIKGPY QHFGYLEGVI
DGILARRTSV ATNVYEVVKA AQSGGIDKPV IFMGDRDDHY TQQSGDGYSA YIGGSKAQAT
HAMNEWWGKK GMGTMPHAMI QLFKGDIVEA CRAYHETFPE DDLMALVDYN NDVITDSLRA
AREFGDTLKG VRVDTSNTLV DKYFTRNPDL LGTFDPRGVN PKLLFGLREA LDREGYNHVK
IVASGGFDAE RISRYEEIKA PVDIYGVGSS LLKLNVPFTG DNVLLNGEHE AKLGRKYRSN
SRMERIDLNE NSVN
//
