ID A0A2W1FCD3_9PLEO Unreviewed; 865 AA.
AC A0A2W1FCD3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ATP-dependent DNA helicase CHL1 {ECO:0000256|ARBA:ARBA00017386};
DE AltName: Full=ATP-dependent DNA helicase chl1 {ECO:0000256|ARBA:ARBA00016387};
DE AltName: Full=Chromosome loss protein 1 {ECO:0000256|ARBA:ARBA00029709};
GN ORFNames=Ptr86124_002831 {ECO:0000313|EMBL:KAI1517530.1}, PtrM4_030390
GN {ECO:0000313|EMBL:KAF7578799.1}, PtrM4_08016
GN {ECO:0000313|EMBL:PWO10731.1};
OS Pyrenophora tritici-repentis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=45151 {ECO:0000313|EMBL:KAF7578799.1, ECO:0000313|Proteomes:UP000245464};
RN [1] {ECO:0000313|EMBL:KAF7578799.1, ECO:0000313|Proteomes:UP000245464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M4 {ECO:0000313|EMBL:KAF7578799.1,
RC ECO:0000313|Proteomes:UP000245464};
RX PubMed=29685100; DOI=10.1186/s12864-018-4680-3;
RA Moolhuijzen P., See P.T., Hane J.K., Shi G., Liu Z., Oliver R.P.,
RA Moffat C.S.;
RT "Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-
RT repentis reveals chromosomal variations and genome plasticity.";
RL BMC Genomics 19:279-279(2018).
RN [2] {ECO:0000313|EMBL:KAI1517530.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=86-124 {ECO:0000313|EMBL:KAI1517530.1};
RA Moolhuijzen P.M., Moffat C.S.;
RL Submitted (MAY-2021) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAI1517530.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=86-124 {ECO:0000313|EMBL:KAI1517530.1};
RA Moolhuijzen P., See P.T., Shi G., Powell H.R., Cockram J., Jorgensen L.N.,
RA Benslimane H., Strelkov S.E., Turner J., Liu Z., Moffat C.S.;
RT "A global pangenome for the wheat fungal pathogen Pyrenophora tritici-
RT repentis and prediction of effector protein structural homology.";
RL bioRxiv 0:0-0(2022).
CC -!- FUNCTION: ATP-dependent DNA helicase important for chromosome
CC transmission and normal cell cycle progression in G(2)/M (By
CC similarity). May have a role in changing DNA topology to allow the
CC loading of proteins involved in maintaining sister chromatid cohesion
CC in the vicinity of the centromeres (By similarity). Has a specific role
CC in chromosome segregation during meiosis II.
CC {ECO:0000256|ARBA:ARBA00025396}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF7578799.1}.
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DR EMBL; NQIK02000001; KAF7578799.1; -; Genomic_DNA.
DR EMBL; NRDI02000003; KAI1517530.1; -; Genomic_DNA.
DR EMBL; NQIK01000006; PWO10731.1; -; Genomic_DNA.
DR Proteomes; UP000245464; Unassembled WGS sequence.
DR Proteomes; UP000249757; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KAF7578799.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 6..421
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 111..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 96548 MW; 36882FAEF7F23FA0 CRC64;
MDQTTPRQDF HHPYTPYDIQ NEFMGAVYKC LEDGKVGIFE SPTGTGKSLS LICGSLTWLR
DHKRRTFEEG FPMDANNSGE PSWIVEHAQK QRKQEALRRK QDLNDRIAKV KAKEKRAKER
YENSEPKHKR QRIATSEASD DHEAQYVLDD YESDEDSHKR AKAGTFDESG LSAETQALMA
SLGYSVDVPK EDDGETPDET KIFFCSRTHS QLTQFSSELG RVKMPPAIAS DDTENGGGIE
SLVEDVKHLT LGSRKNLCIN SQVNRLESAT AINERCLELQ QSSVAETRCP HMPTKESEPL
INDFRDHALA KIRDIEDLGS LGKKLGVCPY YASRPTLKYC EIVTLPYPLL LQRSAREALG
ISLRDHIVII DEAHNLMDAI AGIYSVSVTL EQVQQARTQL TVYLQKFRNK LKGKNRVYVA
QTVRILDSIV AYLQIIHAKP GMSDGLVDMV SIMSGKGVDQ INIYKLNTYL QESRLARKVD
GYTAYAEETK NKDVMVSTKQ VVKKGPRHNV PVLMHVQAFL LSLMNPSTEG RFFYSREEDT
STTLRYMLLD PTFHFKEIVE EARAVVLAGG TMSPMSDYEQ HLLSYLEPSK IMTLSCGHVI
PPSNLLAVPV MRTSGGVEFD FTFENRNKEM TMIDLGTAIL NFSQHIPDGL VVFFPSYAYL
DTCIAAWKRI KPSASKATFW DGFTQSKPVF LEQRSQQQAS DQVPASKDAA VASVLSAYSA
AIASGNGRGA LLFAVIGGTL SEGINFSNAL GRGVVVVGLP FPNAQSAEWK AKMQYIATKT
AKNGGDGKAA ARDFYENACM RAVNQCVGRA IRHKGDYAAI LMLDRRYGSR RIQDKLPKWI
RGSLTTGLGV RDVEGRLDEF FVDKK
//
