ID A0A2W1JSN4_9CYAN Unreviewed; 803 AA.
AC A0A2W1JSN4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Putative 3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:PZD72011.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:PZD72011.1};
GN Name=fadN_1 {ECO:0000313|EMBL:PZD72011.1};
GN ORFNames=C1752_03980 {ECO:0000313|EMBL:PZD72011.1};
OS Acaryochloris thomasi RCC1774.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Acaryochloridales;
OC Acaryochloridaceae; Acaryochloris; Acaryochloris thomasi.
OX NCBI_TaxID=1764569 {ECO:0000313|EMBL:PZD72011.1, ECO:0000313|Proteomes:UP000248857};
RN [1] {ECO:0000313|EMBL:PZD72011.1, ECO:0000313|Proteomes:UP000248857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC1774 {ECO:0000313|EMBL:PZD72011.1,
RC ECO:0000313|Proteomes:UP000248857};
RX PubMed=29904088; DOI=10.1038/s41598-018-27542-7;
RA Partensky F., Six C., Ratin M., Garczarek L., Vaulot D., Probert I.,
RA Calteau A., Gourvil P., Marie D., Grebert T., Bouchier C., Le Panse S.,
RA Gachenot M., Rodriguez F., Garrido J.L.;
RT "A novel species of the marine cyanobacterium Acaryochloris with a unique
RT pigment content and lifestyle.";
RL Sci. Rep. 8:9142-9142(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZD72011.1}.
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DR EMBL; PQWO01000012; PZD72011.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W1JSN4; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000248857; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:PZD72011.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248857}.
FT DOMAIN 8..189
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 193..292
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 366..402
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 803 AA; 89191 MW; 5E8173BC70D0F41E CRC64;
MFKPFRTAAV LGAGVMGTQI AAHLANAGLI VYLLDLPAAG DRKNALVEAA FKKGLKQKPP
IFFTEKTSRR VILGNFEEDW HRLASVDWVV EAVIEKLDVK QQLMARLDGF IREDAVVSTN
TSGLPIHAIA EGRSKSFQQR FLGTHFFNPP RYLKLLELIP TSTTDPEIVK RLEWFGRLHL
GKGVVIAKDT PNFIGNRIGL FVSLLGIRAL TDQGYTIEEI DILTGTLVGR PKSATLRTAD
LVGLDTLTYV AENLYPMIPD DESRDVFLVP QTLRQMVEAS YLGAKTGEGF YKKVGGKILS
LDIQTFNYRK ARPIDLGGLD AIAKIKSLPE RLQALYKDTG RAGTFFRQTT LKILSYSAHR
IPEIADSPSE IDRAMRWGFG WRLGPFEMWD VLGFETVIKD MQASGIAVPS WVEQMQWAGA
HSFYQEIGRE EEDLTQSPHP LHFVYQPQRG YGPIETPRDE FTLAPFKVDP TRTLWQNSEA
ALLDIGDGVV LFEFRSKGNT LSRVVVDGFS EALDLIEEGD YCGLVIGNDG EHFSAGANLA
DMVKFSHQDR VNVFADCEHG AIAKLLDRFQ ALMLRLHYFP QPIVAAIRGR VLGGGCELVM
ACPHVVAAAE TYIGLVELSV GLVPGAGGIM TMATWAAEHA ATDDPSDIQP FLKRAFETIG
TAKVSGSAYE AQEWGYLPPT AEIVMNSDRR LYVAKEEVLR LDHEGYAPPP KRNAIKVLGK
PARALFETAA YLMQKGGYIS EYDRFLANRL AYVITGGDLS APSMVSDDYL LGLEREMFLP
LFGQKKTQER IMHTLRTKKP LRN
//
