ID A0A2W1JVV6_9FLAO Unreviewed; 395 AA.
AC A0A2W1JVV6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=acetyl-CoA C-acyltransferase {ECO:0000256|ARBA:ARBA00024073};
DE EC=2.3.1.16 {ECO:0000256|ARBA:ARBA00024073};
GN ORFNames=DNG35_07500 {ECO:0000313|EMBL:PZD77929.1};
OS Mesonia sp. K7.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Mesonia.
OX NCBI_TaxID=2218606 {ECO:0000313|EMBL:PZD77929.1, ECO:0000313|Proteomes:UP000249791};
RN [1] {ECO:0000313|EMBL:PZD77929.1, ECO:0000313|Proteomes:UP000249791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K7 {ECO:0000313|EMBL:PZD77929.1,
RC ECO:0000313|Proteomes:UP000249791};
RA Lai Q., Shao Z.;
RT "Mesonia sp. K7 draft genome sequence.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZD77929.1}.
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DR EMBL; QKQV01000008; PZD77929.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2W1JVV6; -.
DR OrthoDB; 9764892at2; -.
DR Proteomes; UP000249791; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:PZD77929.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000249791};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:PZD77929.1}.
FT DOMAIN 6..263
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 271..392
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 92
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 349
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 381
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 395 AA; 42962 MW; 6CC3FCCE42C8A3C2 CRC64;
MNKTAYIVKA YRTAVGKSSR GVFRFKRPDD LAAETINYMM NELPEFDKSR IDDVIVGNAM
PEAEQGLNVG RLISLMGLNT VDVAGMTVNR YCASGLETIA IASAKIQSGM ADCIIAGGAE
SMSYIPMGGY KPAPNYDLAK EGKEDYYWGM GLTAEAVANK YKVTREDQDE FAFQSHQKAL
KAQAENRFKD QIVPIDIEEI YFENGKKQTR NYTVNQDEGP RADTSLDALA RLRPVFAQGG
SVTAGNSSQT SDGAAFVMVM SEKMVKELNL EPIARLVSFT AVGVEPKIMG IGPVKAIPKA
IKQAGLQQKD IELIELNEAF ASQSLAVIRE LDLDKEKLNV NGGAISLGHP LGCTGAKLSV
QIFDEMKKRK LNNKYAMVTM CVGTGQGAAG VYEVY
//
