ID A0A2W1LNK6_9BACL Unreviewed; 4095 AA.
AC A0A2W1LNK6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=DNH61_25415 {ECO:0000313|EMBL:PZD92997.1};
OS Paenibacillus sambharensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1803190 {ECO:0000313|EMBL:PZD92997.1, ECO:0000313|Proteomes:UP000249522};
RN [1] {ECO:0000313|EMBL:PZD92997.1, ECO:0000313|Proteomes:UP000249522}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMB1 {ECO:0000313|EMBL:PZD92997.1,
RC ECO:0000313|Proteomes:UP000249522};
RA Pinnaka A.K., Singh H., Kaur M.;
RT "Paenibacillus imtechensis sp. nov.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZD92997.1}.
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DR EMBL; QKRB01000061; PZD92997.1; -; Genomic_DNA.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000249522; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 3.
DR CDD; cd19543; DCL_NRPS; 2.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000249522}.
FT DOMAIN 957..1032
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2017..2091
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3555..3632
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1994..2014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4095 AA; 457334 MW; F22342069898ADA9 CRC64;
MDGVQIKNLY PLTPMQEGML FHSLLDQDHP AYHQQMTLTL KGTINLDYIE QSMNALIARY
DVLRTVFLVE NVEQPLQVVL QERTLTLIQE DIAALPEEEQ RAFIRRYEEE DRRQGFDLTS
DLLMRVSVLV TGADSCAMVW SFHHIIMDGW CLGIILDDFF QAYEALAGGL PVLEKAVYPY
SDYMEWLLQQ DKDGARAYWQ ECLAGYEQQA VVPGMRQDQK DRAYRGSEYE FRFPEALTQK
LEQLAKAQGV TLSTVLQALW GVLLHKYNYS DDVVYGTVVS GRPSSLTGVE QMVGLFINTI
PVRVQSTHGQ TFTELLQAVQ QQSLRSNDNA FFPLAEIQAD SVLRSGLIQH LVVFENYPID
EALDSRYPGL GFAIEDVRVF EQTSYDFNLM VVPGAQLKLA FNYNEAVYDS SFVAAIGGHL
LKLAEAAAGD PAVPLHTIEI ITEAEAEQLA SFNDTAREYP LHKPYMELFA EAVELHRERT
ALVFEDALLT YGELDCRVDR LAARLRGRGV SRESIVGIMV EPSLEMIVGV LAVLKAGGAF
LPIDPGYPQE RVQYFLTDSG AEILLTQTRF IGTISFAGEC LNLEDEQLYN VDVPFPEGRL
PLIGRPDDLA YVIYTSGSTG QPKGVMIEHS ALVNLCFWHN SEYGVTPEDR TAKYAGFSFD
CSVWEIFPYL ICGASIHMLH KDIRLDIGRL NRYFETNSIT ITYLPTQFAE QFMKVQNRSL
RVLLTAGDKL KQYVPQTYKL VNNYGPTENA VITTFYYVDR QQDNIPIGIP VHNHRVYVLD
KGGKQVPAGV PGELCVSGSG LARGYWNKPD LTDEKFTVNP YEPGERMYRT GDLAVWMPDG
NIQYLGRIDQ QVKIRGHRIE IGEIETQLMQ LAAVRDCVVV PLKDDNDQAY LCAYFVPQQE
DMADTKQLRK QLEGLLPDYM VPAVFMELER IPVNVNGKID RKALPKPAVP MVSGYEAPSG
ELENHLAGLW GRVLGLPRVG RQDHFFEMGG HSLKAVMLVT EMQQSIDVPV QIRDIFACPT
VRELAELLEE RRRGHVAPAG GPEGIPAAGV RPYYPLSSAQ RRLYVLSQME GVGTSYHLPG
ALLLEGSLSR EKLEQTVERM LDRHEALRTR FIMADGEPVQ QIMPPSPFRL PVHELHPPAE
HGEGEGLARY IQSYMETQFV RPFELDHAPL MRMELLKLGA DRHVLLYDMH HLITDGTSTA
LFVRDFIELY NEETLAPLEL HYKDYAVWQH ERLAAGESEE DGKYWLNTFA DGIPVLQLPA
DYTRPAVRRF AGNRTVFTVD PAAAARLEQL AADTGSTLYM VLLAAYHLLL AGHSGQRDIV
IGTPVSGRTH ADMHRMLGMF VNTLPLRTVS RPDQTVRELL LGIRELVLQS LEHQDYPFEE
LVHRLAPERD TGRNPLFDTM FALQNMDEEE MKLSGLHVTP LAVQADMAKY DLTLIGSQHG
GGLSFELEYS TDLFHPATIE RWAAHYQELL HLIAREADTA LADVSCLPEQ EKELLLHAFN
RTELLVEDKL LHELFEEQAA RTPDHPALAD SSRRLTFGEL NDRANRLARL LRSEGAAPGQ
IVGVSTDRSV DVVTAMLAIL KAGAAYLPLD PSYPAERLRY FAEDSGVRLI VTNHDAAAGL
LPADGGRVID MRDQALLEQY EGANLPRTAQ SGDLAYVIYT SGSTGLPKGV MIEHRSIAAT
LQWRQTVYRF DGRDTALAIY PYAFDGFIIG CLSPLFGGAA VVMLDEREAR DPAGIRDKVV
SEQATHLMCI PSLYAGILGC SEPGQLKTLR IAALGGERLT AAVVQAHWHH CPETVLVNEY
GPTENSVTST HLVLAGGESD ITIGGPNGNM QAFILDERQR LLPIGVPGEL CVSGAGLARG
YLNRPELTAE KFVDHPYRKG ERLYRTGDLA RFRPDGRIEY LGRIDHQVKI RGYRIELGEI
EEALLACPGV REAVVIDRTG EDGAAYLCAY VVAQQEWNGP LQTGELQASL SGKLPHYMIP
TRFMQLDSIP LAPSGKADRQ ALPEPAAETG SGRRFAAPQG EAEQLLAGIW QEVLGISRIG
REDSFFQLGG DSIKAIQVSS RLYKAGYAME MKELFQEPVL KRFAATLSKA LKRAEQGPVT
GEVPLTPIQR WFFGRRFTDA HHFNQSVVLL RRDRFEPAKL YAVLDKLTQH HDALRAVFHS
SGAGQEPVQI IRGLDGETFD FQVTDMRAEP NPAYQMEQLI ERTQQSFDLH DGPLVKAVLM
QAPEGDHLLL TVHHLVVDGV SWRIMLEDFN LLYRQALEGT PLTLQEKTFS YKDWALALQE
YADTSRLQRE AAYWEDITAA AVEQGPGAFP ADRHADKNTY QTSRSLTASL SEADTSRLLR
QAPQAYGTEV NELLLTALGL AVRDWSGLGQ ALVTLEGHGR EKIRDDLNIS RTVGWFTSTF
PVRLDLAGSR TLADCIQSMK ESMRRIPKRG IGYGILKELG RRSAEQAEAD TGSGIQPAIS
FNYLGQFDQD IASELFELSR LSMGELISPY MERQAELEFN GMVVEGRLTF SLTYNTLQYE
DGTAGRLIGL FRHHLEEIIN HCAQLTETVR TPSDYGCHNL SLQEWAGIQS LAAERRAGIA
DLYPLTPMQE GMLFHALKDA DSSAYVEQMS LQLEGELDEA ALRSSLAVLF DCHPVLRTMF
VYEGLNRPYQ VVLDRMEPVI RLADWSGRAA GEQDELLSRF KQEDLARGFD LTRDPLVRLT
VMKLGGEQWR LVWTHHHILM DGWCLGLLFE DLFTCYEAVL EGRTPEPAAR APYRAYIGWL
QEREREEAAA YWRAYLAGYE EPATLPKSAA GRREGYEQGG VSFTLDRGLT SELNRLASLH
EVTLNTVVQA VWAVVLQRYN DTDEVVFGSV VSGRPPEVAG IEEMIGLFIN TIPVRFRFTG
QSFGKLLQDA KQSALEAMQH DYLSLADIQA VSPLKQHLFD HILVFENTPA HQDGDSRNDR
SRLGFTVADT EVYEQTSYDF DITVGPGEEL FFKFSYNTRV YDEAIIRQLA GHFRQIAEQA
AARPEHPAED LELLTEADKH LLTAGFNARK APVDMQETVP LLFEQQAAAV PDRTAVVFGE
EKHSYEAVNR HANQLAHELS SRGAGHETLV AVLMERSPRM IETILGIWKA GGAYIPVDPD
YPVSRKLAIL QESGVRYMVS ASDYLSDLPE EALSEIDCIL LDQEEEAIVS RSSDNLVPLA
AGDSLAYVIY TSGSTGKPKG AMIEHAGMLN HIAAEIEELS LGSHSVIAQN ANHCFDISVW
QMFAALTIGG TTAIAANDVI LEPQRFLERI AADEVTVLEV VPSYLALLMD EIRVRQGHGL
ALQYLMITGE TVKPAMVKQW FELCPDIRMV NAYGPAEAAD DISQYVMERA PELDPVPIGG
PVRNMNLYIV DRQLRLLPVG AVGEICVSGI GVGRGYLNDE ERTKAVFMED PYAAEKGLRM
YRTGDLGRWL PDGTVAFYGR RDNQVKIRGY RVELGEIEAK LVEHAQVREA VVLDAADSQG
GRYLCAYIVS TGGEISAAEL RKHAAELLPD YMVPSVFLML DEMPLSPNGK IDRRALPQPD
RLQADGWNQA SAEAGTRTEM EQGLAQIWSQ ILGVGAGQIS RAHSFFELGG HSLKAMALVA
QVRGQLGAEL TIRDIFASPV LMEQAALLEG RQSNRTGIIK PAQKRGSYPV SSAQKRMFIA
SQMPGAELSY NIPQFTLMEG RLDEERLRQA LEELVHRHEA LRTSFTLAGG EPVQRIHDDA
RLELEVYRLG GDVEEPAVDE AVQSIIDAFV RPFDLGKAPL MRAGFIRLSE EQTLLMLDVH
HIVSDGVTSG LLAAEFAAFY RGEALPLPAV HYKDFAVWQQ EQMQDELFSR QERYWLEQLA
GELPVLQLPT DYVRPSYKSY AGDRMEFGTD ERLASAIQAR LAETGTTLYM YLLAAFHVLL
SKYSGQQDII VGSPVAGRHY AGLEQVCGMF VNTLPLRIRS SGEWTFGELL EQAKEMALGA
YENQDYPMDE LVPMLQMAAD PGRSPLFDAV LVIQNLDEPE VDLGSVKLRP YPVENKTAKF
DVTLMAVEED GRLSFSMEYC TALFRQETIR QMTDDYCRIL QTVAVDPMIR LDDIRLSETP
AVEDRAIDGD IVFEL
//
